APOL3

apolipoprotein L3

Summary

This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Known Variants37 total

rsidPosition (GRCh37)AllelesClassClinVar
rs76473798622:36,537,262A/Guncertain significance
rs77432276722:36,537,273C/Tlikely benign
rs37164398822:36,537,328G/Auncertain significance
rs76533678022:36,537,445G/Auncertain significance
rs53526618822:36,537,466G/Auncertain significance
rs146465289622:36,537,479A/Cuncertain significance
rs37298169122:36,537,537A/Guncertain significance
rs75718071222:36,537,570C/Tuncertain significance
rs20165867922:36,537,585A/Guncertain significance
rs141252095622:36,537,640T/Auncertain significance
rs20073249322:36,537,645C/Tlikely benign
rs205999634722:36,537,723G/Auncertain significance
rs20134389822:36,537,771G/Auncertain significance
rs14205752022:36,537,775C/Tbenign
rs252756494522:36,537,780A/Guncertain significance
rs77901689422:36,537,783C/Tuncertain significance
rs11614725722:36,537,798G/Abenign
rs14561747922:36,537,812C/Tlikely benign
rs252756677922:36,537,843C/Auncertain significance
rs142202948422:36,537,937C/Tuncertain significance
rs600015222:36,538,053G/Abenign
rs36896935722:36,538,062G/Auncertain significance
rs136849645922:36,538,105C/Guncertain significance
rs8057522:36,539,754G/A
rs20143213422:36,541,567T/Cbenign
rs76646334722:36,541,617T/Cuncertain significance
rs252762400322:36,541,632G/Auncertain significance
rs7941941122:36,556,729T/Cbenign
rs251779119622:36,556,741G/Auncertain significance
rs14888522622:36,556,836C/Alikely benign
rs123715051022:36,556,839T/Guncertain significance
rs14582810322:36,556,874G/Abenign
rs133080083822:36,556,881C/Tuncertain significance
rs74689014122:36,556,888T/Cuncertain significance
rs14112010122:36,556,901A/Clikely benign
rs76263393322:36,556,909C/Tuncertain significance
rs214690933922:36,556,923C/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.