ARAF
A-Raf proto-oncogene, serine/threonine kinase
Summary
Enables protein serine/threonine kinase activity. Involved in negative regulation of apoptotic process; regulation of TOR signaling; and regulation of protein metabolic process. Predicted to be active in cytosol and mitochondrion. Biomarker of high grade glioma. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants29 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs749564014 | X:47,422,403 | G/A | — | uncertain significance |
| rs766226234 | X:47,422,618 | C/T | — | uncertain significance |
| rs755693043 | X:47,422,654 | C/T | — | likely benign |
| rs779648831 | X:47,424,409 | C/T | — | uncertain significance |
| rs774526444 | X:47,424,529 | A/G | — | uncertain significance |
| rs746126878 | X:47,424,531 | C/T | — | uncertain significance |
| rs2519673611 | X:47,424,676 | T/C | — | uncertain significance |
| rs146376823 | X:47,424,690 | A/T | — | uncertain significance |
| rs371247311 | X:47,424,707 | C/T | — | uncertain significance |
| rs143159753 | X:47,424,734 | C/A | — | uncertain significance |
| rs372462744 | X:47,426,051 | C/T | — | uncertain significance |
| rs780758789 | X:47,426,079 | C/G | — | uncertain significance |
| rs1057519876 | X:47,426,120 | T/A | missense variant | — |
| rs1057519786 | X:47,426,121 | C/G | missense variant | — |
| rs2519675071 | X:47,426,130 | A/G | — | uncertain significance |
| rs368024349 | X:47,426,176 | C/G | — | uncertain significance |
| rs142304168 | X:47,426,442 | G/T | — | uncertain significance |
| rs923151586 | X:47,426,465 | C/G | — | uncertain significance |
| rs777457066 | X:47,426,512 | C/T | — | likely benign |
| rs143311445 | X:47,426,689 | C/G | — | uncertain significance |
| rs2519676737 | X:47,426,753 | T/C | — | uncertain significance |
| rs56322617 | X:47,426,757 | C/T | — | benign |
| rs2519677846 | X:47,428,146 | T/G | — | uncertain significance |
| rs2057743722 | X:47,428,223 | C/T | — | uncertain significance |
| rs959306158 | X:47,428,272 | G/A | — | uncertain significance |
| rs62636604 | X:47,429,050 | G/A | — | benign |
| rs2519679564 | X:47,429,381 | G/A | — | uncertain significance |
| rs2057748544 | X:47,429,400 | A/G | — | uncertain significance |
| rs55852926 | X:47,430,769 | G/C | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.