ARF5
ARF GTPase 5
Summary
This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. [provided by RefSeq, Dec 2010]
Known Variants6 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs912240810 | 7:127,229,542 | T/A | — | uncertain significance |
| rs62483173 | 7:127,230,676 | T/C | upstream gene variant | — |
| rs775287559 | 7:127,231,097 | C/A | — | uncertain significance |
| rs751785636 | 7:127,231,131 | C/T | — | uncertain significance |
| rs77229708 | 7:127,231,302 | A/C | — | benign |
| rs773554378 | 7:127,231,348 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.