ARHGAP6

Rho GTPase activating protein 6

Summary

This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Known Variants72 total

rsidPosition (GRCh37)AllelesClassClinVar
rs755537648X:11,138,167T/Clikely benign
rs781454003X:11,157,005G/Auncertain significance
rs1329074511X:11,157,006C/Tlikely benign
rs770508263X:11,157,054T/Cuncertain significance
rs763040938X:11,157,119T/Auncertain significance
rs1469592263X:11,157,124G/Alikely benign
rs139894176X:11,157,132G/Abenign
rs201148704X:11,157,162C/Tuncertain significance
rs199981819X:11,157,189G/Cbenign
rs188030198X:11,157,198C/Abenign
rs767639041X:11,157,206G/Tuncertain significance
rs201221649X:11,157,272C/Tuncertain significance
rs1320911529X:11,157,273G/Auncertain significance
rs1317708944X:11,157,315G/Tuncertain significance
rs760999481X:11,157,320G/Cuncertain significance
rs982285428X:11,157,324G/Auncertain significance
rs761461918X:11,157,336C/Tuncertain significance
rs1260392486X:11,157,348G/Cuncertain significance
rs113239937X:11,157,385C/Tbenign
rs951058337X:11,157,403G/Alikely benign
rs777711140X:11,157,414G/Auncertain significance
rs2045588892X:11,157,474G/Auncertain significance
rs754423051X:11,157,527G/Auncertain significance
rs1602721512X:11,160,366G/Alikely benign
rs72558047X:11,160,419G/Tlikely benign
rs756872843X:11,162,005C/Tlikely benign
rs751497467X:11,162,144G/Auncertain significance
rs985013029X:11,162,194C/Tlikely benign
rs140286676X:11,162,197C/Tbenign
rs2518495297X:11,162,225A/Guncertain significance
rs367721228X:11,162,373C/Alikely benign
rs769596416X:11,187,669C/Tlikely benign
rs898986058X:11,187,695C/Tuncertain significance
rs483352735X:11,187,759C/Auncertain significance
rs72558043X:11,196,250G/Abenign
rs72558042X:11,196,271G/Tbenign
rs777197971X:11,196,288G/Auncertain significance
rs2518561862X:11,197,566C/Tuncertain significance
rs373458914X:11,200,187C/Tuncertain significance
rs1404266777X:11,204,374G/Tuncertain significance
rs45624238X:11,204,390C/Tbenign
rs144289365X:11,204,433T/Cuncertain significance
rs199543482X:11,204,450C/Guncertain significance
rs1362203481X:11,207,018C/Guncertain significance
rs146662506X:11,207,098A/Cuncertain significance
rs138271349X:11,209,184C/Tintron variant
rs975870818X:11,215,096A/Guncertain significance
rs1490202272X:11,272,782T/Glikely benign
rs1473292516X:11,272,836C/Alikely benign
rs17321447X:11,283,825G/T
rs777487143X:11,284,011G/Alikely benign
rs5979390X:11,295,309C/Tintron variant
rs150568503X:11,330,819T/Gintron variant
rs2788524X:11,339,211G/Aupstream gene variant
rs12388118X:11,380,742T/G
rs5935037X:11,381,616G/Aregulatory region variant
rs5933886X:11,463,381C/Tintron variant
rs750456871X:11,682,375C/Auncertain significance
rs111800080X:11,682,379G/Abenign
rs2052730718X:11,682,405G/Cuncertain significance
rs770537973X:11,682,458T/Cuncertain significance
rs144462941X:11,682,470C/Aconflicting classifications of pathogenicity
rs756671029X:11,682,533A/Guncertain significance
rs1188248646X:11,682,565G/Tlikely benign
rs201256787X:11,682,602C/Tuncertain significance
rs1257879828X:11,682,605G/Tuncertain significance
rs1199653478X:11,682,612A/Cuncertain significance
rs376163184X:11,682,654G/Aconflicting classifications of pathogenicity
rs1368452423X:11,682,758C/Guncertain significance
rs2519243927X:11,682,768T/Guncertain significance
rs769616573X:11,682,773C/Tuncertain significance
rs774547900X:11,682,778C/Tlikely benign

Gene information from NCBI Gene. Variant classifications from ClinVar.