ARPC1A

actin related protein 2/3 complex subunit 1A

Summary

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Known Variants18 total

rsidPosition (GRCh37)AllelesClassClinVar
rs2009846447:98,931,658A/G
rs5620999387:98,935,854G/Auncertain significance
rs1999889497:98,935,900A/Guncertain significance
rs25358232047:98,941,945A/Guncertain significance
rs7495058177:98,942,054A/Cuncertain significance
rs13419906777:98,946,543A/Guncertain significance
rs1500091667:98,951,612T/Cuncertain significance
rs1452234747:98,951,630G/Tuncertain significance
rs7736883647:98,951,674A/Guncertain significance
rs7605965207:98,951,713G/Auncertain significance
rs25358387487:98,956,000A/Tuncertain significance
rs733955807:98,956,755C/Tintron variant
rs7769346957:98,957,292A/Guncertain significance
rs7401607:98,957,880C/Tintron variant
rs13366856847:98,961,204G/Auncertain significance
rs9873261577:98,961,236A/Cuncertain significance
rs1872963477:98,961,242A/Guncertain significance
rs1886487177:98,963,541C/Tuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.