ATF7
activating transcription factor 7
Summary
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; mitogen-activated protein kinase binding activity; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of RNA polymerase II transcription regulator complex. Biomarker of colorectal cancer. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants11 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs12321906 | 12:53,916,715 | T/C | intron variant | — |
| rs2229306 | 12:53,918,438 | T/C | — | benign |
| rs1458520743 | 12:53,923,155 | T/A | — | — |
| rs111535462 | 12:53,923,641 | C/T | intron variant | — |
| rs71455251 | 12:53,940,862 | G/A | intron variant | — |
| rs10467109 | 12:53,971,326 | C/A | — | — |
| rs1485395 | 12:53,995,077 | T/C | intron variant | — |
| rs574693676 | 12:54,005,444 | G/A | — | — |
| rs3852552 | 12:54,009,395 | C/T | intron variant | — |
| rs2365344 | 12:54,009,977 | T/A | regulatory region variant | — |
| rs181969679 | 12:54,011,729 | A/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.