ATP2C2

ATPase secretory pathway Ca2+ transporting 2

Summary

Enables P-type calcium transporter activity and P-type manganese transporter activity. Predicted to be involved in calcium ion transmembrane transport; intracellular calcium ion homeostasis; and manganese ion transport. Predicted to act upstream of or within mammary gland epithelium development; positive regulation of calcium ion import; and protein localization to plasma membrane. Predicted to be located in trans-Golgi network membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants212 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs751507227	16:84,402,229	A/G	—	uncertain significance
rs1019657377	16:84,402,262	G/A	—	uncertain significance
rs2507917861	16:84,402,276	G/A	—	uncertain significance
rs200013593	16:84,402,286	A/G	—	likely benign
rs367638985	16:84,402,316	C/G	—	uncertain significance
rs149058210	16:84,422,169	A/C	intron variant	—
rs8048576	16:84,423,034	G/T	—	—
rs377216368	16:84,432,159	C/T	—	likely benign
rs780617194	16:84,432,175	C/T	—	uncertain significance
rs4782948	16:84,432,176	A/G	—	likely benign
rs201569578	16:84,438,759	A/T	—	conflicting classifications of pathogenicity
rs369766004	16:84,438,793	C/G	—	likely benign
rs545270710	16:84,438,820	C/T	—	likely benign
rs201061113	16:84,438,821	G/A	—	uncertain significance
rs78887288	16:84,438,827	G/A	—	conflicting classifications of pathogenicity
rs374918518	16:84,442,006	T/G	—	likely benign
rs779347213	16:84,442,061	C/A	—	likely benign
rs78371901	16:84,442,095	G/A	—	benign
rs374685827	16:84,444,196	T/C	—	uncertain significance
rs1479094043	16:84,444,204	A/T	—	uncertain significance
rs80149007	16:84,444,206	C/T	—	likely benign
rs759438706	16:84,444,339	G/C	—	uncertain significance
rs371412681	16:84,444,359	C/T	—	uncertain significance
rs10514604	16:84,446,384	C/G	intron variant	—
rs2508100338	16:84,449,097	A/G	—	uncertain significance
rs374182719	16:84,449,108	C/G	—	uncertain significance
rs561980766	16:84,449,124	G/A	—	uncertain significance
rs375031013	16:84,449,146	C/A	—	likely benign
rs1246302728	16:84,449,151	C/A	—	uncertain significance
rs3743651	16:84,449,161	T/C	—	benign
rs200595572	16:84,449,174	C/G	—	uncertain significance
rs750932659	16:84,449,187	G/A	—	uncertain significance
rs184593151	16:84,456,032	G/A	—	uncertain significance
rs372288677	16:84,456,040	C/T	—	likely benign
rs538038991	16:84,456,044	C/T	—	uncertain significance
rs1188158770	16:84,456,085	C/G	—	uncertain significance
rs752270464	16:84,456,125	G/T	—	uncertain significance
rs373166793	16:84,456,132	A/G	—	likely benign
rs74038217	16:84,456,138	G/A	—	benign
rs200739405	16:84,456,143	C/G	—	uncertain significance
rs267604665	16:84,456,256	G/A	—	uncertain significance
rs1487097192	16:84,456,294	G/T	—	uncertain significance
rs200531713	16:84,456,800	A/G	—	uncertain significance
rs748337996	16:84,456,838	G/C	—	uncertain significance
rs758188902	16:84,456,854	T/C	—	uncertain significance
rs2508159720	16:84,456,855	C/G	—	uncertain significance
rs370676847	16:84,456,878	A/G	—	likely benign
rs1907752548	16:84,459,346	A/C	—	uncertain significance
rs771189845	16:84,459,349	A/G	—	uncertain significance
rs746333499	16:84,459,356	T/C	—	likely benign
rs62640932	16:84,459,376	C/G	—	conflicting classifications of pathogenicity
rs1367249911	16:84,459,382	C/A	—	uncertain significance
rs200143283	16:84,459,400	G/A	—	uncertain significance
rs377016980	16:84,472,764	C/T	—	likely benign
rs150034273	16:84,472,765	G/A	—	benign
rs80000075	16:84,472,775	G/T	—	benign
rs2507339912	16:84,472,776	G/C	—	uncertain significance
rs745605167	16:84,472,785	G/A	—	uncertain significance
rs62640931	16:84,472,787	C/T	—	benign
rs376382339	16:84,472,804	C/T	—	uncertain significance
rs374715934	16:84,472,812	G/A	—	uncertain significance
rs180864274	16:84,472,836	G/C	—	uncertain significance
rs368020130	16:84,472,842	C/T	—	uncertain significance
rs201782040	16:84,472,849	C/T	—	uncertain significance
rs201256097	16:84,472,858	G/A	—	uncertain significance
rs199936161	16:84,472,875	T/C	—	likely benign
rs202026876	16:84,473,044	G/A	—	likely benign
rs780950794	16:84,473,063	C/T	—	uncertain significance
rs200192229	16:84,473,081	A/G	—	likely benign
rs201133834	16:84,473,098	C/G	—	uncertain significance
rs752496416	16:84,473,122	C/T	—	uncertain significance
rs186501679	16:84,473,123	G/A	—	likely benign
rs1257771979	16:84,473,126	C/T	—	uncertain significance
rs747338600	16:84,474,453	C/T	—	likely benign
rs2303853	16:84,474,484	A/G	—	benign
rs374344981	16:84,474,539	A/G	—	uncertain significance
rs761064727	16:84,476,134	A/G	—	uncertain significance
rs2507352865	16:84,476,151	G/C	—	uncertain significance
rs571704999	16:84,476,176	G/A	—	uncertain significance
rs1300234432	16:84,476,186	T/G	—	uncertain significance
rs771563962	16:84,476,191	G/T	—	uncertain significance
rs247897	16:84,476,200	A/T	—	benign
rs376718837	16:84,479,955	A/C	—	benign
rs2507364313	16:84,479,966	T/C	—	uncertain significance
rs766519223	16:84,479,968	A/G	—	uncertain significance
rs531822897	16:84,480,011	C/T	—	uncertain significance
rs376130916	16:84,480,012	G/A	—	likely benign
rs749731042	16:84,480,031	A/G	—	uncertain significance
rs138818397	16:84,482,136	A/G	—	likely benign
rs1052460523	16:84,482,143	A/T	—	uncertain significance
rs1037890927	16:84,482,191	A/C	—	uncertain significance
rs369706039	16:84,482,246	G/A	—	likely benign
rs756541688	16:84,482,257	T/C	—	uncertain significance
rs779261195	16:84,482,263	A/G	—	uncertain significance
rs748001997	16:84,482,267	G/A	—	likely benign
rs926742835	16:84,482,269	A/C	—	uncertain significance
rs62640930	16:84,482,279	G/A	—	likely benign
rs201848760	16:84,485,547	C/A	—	likely benign
rs754466021	16:84,485,548	C/G	—	uncertain significance
rs200318788	16:84,485,550	G/A	—	conflicting classifications of pathogenicity

Showing 100 of 212 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.