BAG1

BAG cochaperone 1

Summary

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]

Known Variants26 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7061159:33,253,605C/G3 prime UTR variant
rs1384224409:33,255,294C/Tuncertain significance
rs7453155979:33,255,305G/Auncertain significance
rs1142255509:33,255,901T/Cbenign
rs7597809189:33,255,912T/Cuncertain significance
rs5382178109:33,259,013C/Tuncertain significance
rs1453284009:33,261,092C/Tuncertain significance
rs3765089169:33,261,107C/Tuncertain significance
rs24893305559:33,261,136C/Guncertain significance
rs7625825509:33,261,150T/Cuncertain significance
rs5654411069:33,262,733C/Tuncertain significance
rs2006779709:33,262,744T/Cuncertain significance
rs1845588039:33,263,687G/Aregulatory region variant
rs7620280369:33,264,262C/Auncertain significance
rs10069951969:33,264,282T/Cuncertain significance
rs3680345999:33,264,327T/Clikely benign
rs7712057249:33,264,345C/Tuncertain significance
rs7473073479:33,264,429G/Auncertain significance
rs14321459799:33,264,479G/Auncertain significance
rs7520818239:33,264,483C/Tuncertain significance
rs1875621799:33,264,527G/Cuncertain significance
rs24893368839:33,264,539C/Auncertain significance
rs7578211829:33,264,542G/Auncertain significance
rs7721122099:33,264,600G/Auncertain significance
rs13839930309:33,264,627G/Auncertain significance
rs5380540249:33,264,659C/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.