BFAR
bifunctional apoptosis regulator
Summary
Enables caspase binding activity; protein-macromolecule adaptor activity; and ubiquitin protein ligase activity. Involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Acts upstream of or within negative regulation of apoptotic process. Located in endoplasmic reticulum and membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants28 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs143466828 | 16:14,738,273 | G/A | — | likely benign |
| rs537276007 | 16:14,738,304 | G/A | — | uncertain significance |
| rs1329630315 | 16:14,738,337 | C/T | — | uncertain significance |
| rs761912529 | 16:14,738,367 | G/A | — | uncertain significance |
| rs1411969387 | 16:14,738,397 | C/T | — | uncertain significance |
| rs138008477 | 16:14,742,276 | A/G | — | uncertain significance |
| rs754325463 | 16:14,742,278 | T/G | — | uncertain significance |
| rs1959868163 | 16:14,742,354 | G/C | — | uncertain significance |
| rs759302751 | 16:14,742,363 | C/T | — | uncertain significance |
| rs760264750 | 16:14,742,372 | C/G | — | uncertain significance |
| rs1206475035 | 16:14,743,706 | G/C | — | uncertain significance |
| rs1325586957 | 16:14,743,820 | G/C | — | uncertain significance |
| rs142713532 | 16:14,743,923 | G/T | — | — |
| rs539124155 | 16:14,743,968 | C/T | — | — |
| rs768962951 | 16:14,749,017 | C/T | — | uncertain significance |
| rs35377618 | 16:14,749,018 | G/A | — | benign |
| rs146982533 | 16:14,749,020 | G/A | — | uncertain significance |
| rs142229539 | 16:14,749,042 | C/A | — | uncertain significance |
| rs757890136 | 16:14,749,060 | A/G | — | uncertain significance |
| rs2508789026 | 16:14,755,780 | T/C | — | uncertain significance |
| rs375012268 | 16:14,755,835 | C/G | — | uncertain significance |
| rs62037487 | 16:14,756,461 | C/T | intron variant | — |
| rs1460593675 | 16:14,758,742 | C/T | — | uncertain significance |
| rs760068553 | 16:14,758,753 | T/C | — | uncertain significance |
| rs137925406 | 16:14,758,778 | C/G | — | uncertain significance |
| rs1960404989 | 16:14,758,911 | G/T | — | uncertain significance |
| rs1246290045 | 16:14,758,913 | C/T | — | uncertain significance |
| rs777625063 | 16:14,761,658 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.