BID
BH3 interacting domain death agonist
Summary
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Aug 2020]
Known Variants26 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs538615870 | 22:18,220,812 | G/A | — | uncertain significance |
| rs778228540 | 22:18,220,859 | A/G | — | uncertain significance |
| rs547322681 | 22:18,220,871 | G/A | — | uncertain significance |
| rs140738257 | 22:18,220,915 | C/T | — | uncertain significance |
| rs2518658023 | 22:18,220,974 | T/C | — | likely benign |
| rs142609840 | 22:18,220,991 | C/T | — | uncertain significance |
| rs748334233 | 22:18,222,161 | A/C | — | uncertain significance |
| rs575351241 | 22:18,222,170 | G/A | — | uncertain significance |
| rs775453548 | 22:18,222,173 | G/A | — | uncertain significance |
| rs758447724 | 22:18,222,215 | C/T | — | uncertain significance |
| rs148107209 | 22:18,222,228 | G/A | — | uncertain significance |
| rs768772704 | 22:18,222,251 | G/C | — | uncertain significance |
| rs771344517 | 22:18,226,604 | C/G | — | uncertain significance |
| rs2072392 | 22:18,226,612 | A/G | synonymous variant | — |
| rs2518667040 | 22:18,226,614 | C/T | — | uncertain significance |
| rs764590275 | 22:18,226,692 | G/A | — | uncertain significance |
| rs8190315 | 22:18,226,764 | T/C | missense variant | — |
| rs406388 | 22:18,226,997 | C/G | intron variant | — |
| rs1296685 | 22:18,230,964 | A/C | — | — |
| rs8190303 | 22:18,231,014 | G/A | intron variant | — |
| rs762745532 | 22:18,232,905 | C/T | — | uncertain significance |
| rs551411656 | 22:18,232,915 | C/T | — | uncertain significance |
| rs183393610 | 22:18,252,442 | G/A | intron variant | — |
| rs144085890 | 22:18,256,403 | G/T | — | uncertain significance |
| rs750118574 | 22:18,256,424 | C/A | — | uncertain significance |
| rs1210000443 | 22:18,256,449 | T/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.