BRD7
bromodomain containing 7
Summary
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Known Variants31 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7195228 | 16:50,353,529 | C/A | — | — |
| rs796065051 | 16:50,353,864 | G/A | stop gained | pathogenic |
| rs2037018887 | 16:50,353,906 | G/C | — | uncertain significance |
| rs757240104 | 16:50,354,167 | A/T | — | uncertain significance |
| rs1597018664 | 16:50,354,627 | G/A | — | uncertain significance |
| rs779839531 | 16:50,354,658 | A/C | — | uncertain significance |
| rs201216846 | 16:50,354,676 | C/T | — | likely benign |
| rs1188643017 | 16:50,355,916 | G/C | — | uncertain significance |
| rs781074810 | 16:50,357,526 | T/A | — | uncertain significance |
| rs768973311 | 16:50,357,556 | C/G | — | uncertain significance |
| rs375373205 | 16:50,359,744 | A/T | — | uncertain significance |
| rs114435956 | 16:50,360,204 | C/T | — | uncertain significance |
| rs763169889 | 16:50,360,288 | G/A | — | uncertain significance |
| rs755833534 | 16:50,367,513 | T/C | — | uncertain significance |
| rs781455203 | 16:50,368,682 | C/A | — | uncertain significance |
| rs142576342 | 16:50,384,012 | G/C | — | uncertain significance |
| rs374103400 | 16:50,388,359 | A/T | — | uncertain significance |
| rs2508796257 | 16:50,388,376 | G/C | — | uncertain significance |
| rs749452040 | 16:50,388,391 | C/T | — | uncertain significance |
| rs201103198 | 16:50,388,719 | A/T | — | uncertain significance |
| rs2508800419 | 16:50,388,773 | A/G | — | uncertain significance |
| rs761684374 | 16:50,388,787 | T/C | — | uncertain significance |
| rs1481964024 | 16:50,388,796 | T/C | — | uncertain significance |
| rs150539401 | 16:50,388,805 | C/T | — | uncertain significance |
| rs3901517 | 16:50,391,386 | C/G | intron variant | — |
| rs776712836 | 16:50,402,044 | T/C | — | uncertain significance |
| rs772752642 | 16:50,402,097 | A/T | — | uncertain significance |
| rs145220538 | 16:50,402,112 | G/C | — | likely benign |
| rs201842421 | 16:50,402,123 | A/G | — | uncertain significance |
| rs771992785 | 16:50,402,671 | G/T | — | uncertain significance |
| rs1380828577 | 16:50,402,681 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.