BRSK2

BR serine/threonine kinase 2

Summary

Enables several functions, including ATP binding activity; ATPase binding activity; and magnesium ion binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of insulin secretion involved in cellular response to glucose stimulus. Located in centrosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants178 total

rsidPosition (GRCh37)AllelesClassClinVar
rs11206683711:1,411,501C/T—benign
rs53336003711:1,411,533G/A—uncertain significance
rs89784162611:1,411,539G/A—uncertain significance
rs253890884611:1,411,596G/C—likely pathogenic
rs57468623711:1,417,602G/A——
rs143976397511:1,432,625G/A—likely benign
rs95497746611:1,432,653C/T—uncertain significance
rs55362173711:1,432,675G/A—uncertain significance
rs6186896011:1,432,691T/C—benign
rs76680429011:1,432,709C/G—likely benign
rs57748100111:1,432,754C/T—likely benign
rs74881537711:1,432,802C/T—likely benign
rs253904251211:1,432,815C/T—uncertain significance
rs14459214711:1,435,894G/Aintron variant—
rs6186897011:1,444,914G/Aregulatory region variant—
rs1229048511:1,456,484G/Aintron variant—
rs75057550511:1,457,266G/A—likely benign
rs20029964011:1,457,267C/T—likely benign
rs253934522211:1,457,275G/A—uncertain significance
rs77751205811:1,457,298C/T—likely benign
rs213300723211:1,457,333G/C—uncertain significance
rs76669370111:1,457,351C/T—uncertain significance
rs134120108111:1,457,360T/C—uncertain significance
rs185061652711:1,459,543G/A—uncertain significance
rs159053597511:1,459,551G/T—uncertain significance
rs159053610611:1,459,558T/C—uncertain significance
rs126763568911:1,459,567T/C—uncertain significance
rs36791773911:1,462,011C/T—likely benign
rs75614868411:1,462,072G/A—likely benign
rs37685789611:1,462,087G/A—likely benign
rs77201343911:1,462,112C/T—uncertain significance
rs253943151011:1,462,128C/T—uncertain significance
rs253943223911:1,462,154A/G—uncertain significance
rs20156520311:1,463,756C/T—likely benign
rs185148651411:1,463,778G/A—likely pathogenic
rs6174244711:1,463,795G/A—benign
rs253947059411:1,463,806T/C—uncertain significance
rs253947097811:1,463,833G/A—uncertain significance
rs155490415911:1,463,837G/A—pathogenic
rs89193333211:1,464,331C/T—likely benign
rs36833598211:1,464,332G/A—likely benign
rs253948221311:1,464,338C/T—uncertain significance
rs134747981711:1,464,342C/T—likely benign
rs253948267311:1,464,353G/A—uncertain significance
rs128799401011:1,464,354C/T—likely benign
rs11466560611:1,464,382C/T—benign
rs213309543511:1,464,572A/G—uncertain significance
rs77010389111:1,464,594C/T—likely benign
rs37739691711:1,464,606C/T—likely benign
rs77428761711:1,464,616C/T—likely benign
rs155490477211:1,464,720G/A—likely pathogenic
rs213309773711:1,464,767G/A—uncertain significance
rs77931187811:1,464,774G/A—uncertain significance
rs77231918711:1,464,787C/A—uncertain significance
rs213309878411:1,464,852C/T—uncertain significance
rs75896464011:1,464,854C/T—uncertain significance
rs57653997811:1,464,864C/A—uncertain significance
rs96510714711:1,466,222A/G—uncertain significance
rs77030092611:1,466,241C/T—likely benign
rs75157884711:1,466,516G/A—likely benign
rs147437499611:1,466,526G/C—uncertain significance
rs253953830011:1,466,533G/T—uncertain significance
rs20140922411:1,466,542C/T—likely benign
rs74886821711:1,466,543G/C—uncertain significance
rs253953901711:1,466,560T/C—likely benign
rs120411801011:1,466,580G/A—uncertain significance
rs37163108711:1,466,605C/T—likely benign
rs185188943911:1,466,609C/A—uncertain significance
rs5636997511:1,466,611C/T—likely benign
rs213311993111:1,466,629G/A—uncertain significance
rs213312003311:1,466,648C/T—pathogenic
rs37578545911:1,466,649G/A—uncertain significance
rs126229507811:1,466,666C/T—likely benign
rs37694688811:1,466,794G/A—likely benign
rs253954701611:1,466,800G/C—pathogenic
rs75802966211:1,466,807C/T—likely benign
rs18173241311:1,466,834C/T—likely benign
rs37115236811:1,466,858G/C—likely benign
rs213312330511:1,466,889A/G—uncertain significance
rs19991940511:1,466,891C/T—likely benign
rs37617747911:1,466,977C/T—likely benign
rs185196729711:1,466,984C/T—uncertain significance
rs37001876511:1,467,015G/A—likely benign
rs74919127311:1,467,031G/A—uncertain significance
rs3489316711:1,467,054A/G—benign
rs125235592211:1,467,070A/G—uncertain significance
rs104356000511:1,467,071G/C—uncertain significance
rs56453090811:1,467,072C/T—likely benign
rs37436707411:1,467,073G/A—uncertain significance
rs37455806411:1,467,081C/T—likely benign
rs20120416211:1,467,082G/A—likely benign
rs20145948911:1,467,084C/T—likely benign
rs19970124511:1,467,093G/A—likely benign
rs74665889411:1,467,107G/A—likely benign
rs156486765511:1,471,011G/A—uncertain significance
rs37100415611:1,471,021C/T—likely benign
rs20036898011:1,471,027C/G—likely benign
rs53778540411:1,471,491C/T—likely benign
rs37292918311:1,471,565G/A—likely benign
rs57656677811:1,471,583G/A—benign

Showing 100 of 178 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.