CARD10

caspase recruitment domain family member 10

Summary

The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]

Known Variants94 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs2517793087	22:37,887,201	G/T	—	uncertain significance
rs151290630	22:37,887,219	C/T	—	benign
rs2517793119	22:37,887,224	T/G	—	uncertain significance
rs768604345	22:37,887,237	C/T	—	uncertain significance
rs200553561	22:37,887,241	C/G	—	uncertain significance
rs753305136	22:37,887,277	G/A	—	uncertain significance
rs1447230769	22:37,887,284	C/G	—	likely benign
rs55875977	22:37,887,806	G/A	—	benign
rs762662124	22:37,887,818	C/G	—	uncertain significance
rs759948361	22:37,887,838	G/A	—	uncertain significance
rs367817035	22:37,887,862	G/T	—	uncertain significance
rs2517795752	22:37,888,540	C/T	—	uncertain significance
rs377009692	22:37,888,769	C/T	—	benign
rs2517796086	22:37,888,792	T/C	—	uncertain significance
rs201794655	22:37,888,801	G/A	—	risk factor
rs371884305	22:37,888,816	C/G	—	likely benign
rs150625133	22:37,891,546	C/T	—	uncertain significance
rs746726047	22:37,891,556	G/A	—	uncertain significance
rs2517799347	22:37,891,788	C/A	—	uncertain significance
rs141880624	22:37,891,841	C/T	—	likely benign
rs143997223	22:37,891,957	C/T	—	benign
rs148648878	22:37,891,958	G/A	—	likely benign
rs1216184790	22:37,892,459	T/G	—	uncertain significance
rs780670759	22:37,892,522	C/T	—	uncertain significance
rs2517800347	22:37,892,537	C/T	—	uncertain significance
rs942982585	22:37,893,060	G/A	—	uncertain significance
rs1427102872	22:37,893,081	G/A	—	uncertain significance
rs2517801194	22:37,893,105	A/C	—	uncertain significance
rs201385412	22:37,893,107	C/T	—	likely benign
rs201423754	22:37,893,171	C/T	—	uncertain significance
rs562739778	22:37,893,172	G/A	—	uncertain significance
rs1462313356	22:37,898,662	C/A	—	uncertain significance
rs143277306	22:37,899,198	T/C	—	uncertain significance
rs3817802	22:37,900,243	G/A	—	benign
rs1273706151	22:37,900,254	G/C	—	uncertain significance
rs3817803	22:37,900,276	A/G	—	benign
rs61752257	22:37,900,286	T/C	—	benign
rs773124059	22:37,900,662	C/T	—	uncertain significance
rs768266973	22:37,900,677	C/T	—	uncertain significance
rs150575230	22:37,900,720	G/A	—	benign
rs755439574	22:37,900,734	T/A	—	uncertain significance
rs3817805	22:37,900,762	G/A	—	benign
rs3817806	22:37,900,771	A/G	—	benign
rs144504964	22:37,900,772	C/T	—	uncertain significance
rs370693557	22:37,902,192	C/T	—	likely benign
rs374177056	22:37,902,193	G/A	—	likely benign
rs760133266	22:37,902,215	C/A	—	uncertain significance
rs61742320	22:37,902,235	A/C	—	benign
rs145035525	22:37,902,274	C/T	—	benign
rs201397783	22:37,902,275	G/A	—	uncertain significance
rs372472560	22:37,902,311	C/T	—	uncertain significance
rs748488870	22:37,902,324	G/A	—	pathogenic
rs750643216	22:37,902,372	G/A	—	risk factor
rs9619680	22:37,903,878	A/G	—	benign
rs61746683	22:37,903,883	C/T	—	benign
rs752695269	22:37,903,886	T/C	—	uncertain significance
rs573923792	22:37,903,921	G/A	—	uncertain significance
rs150236189	22:37,903,924	C/T	—	uncertain significance
rs145143750	22:37,904,528	A/C	—	benign
rs2517812717	22:37,904,544	A/C	—	uncertain significance
rs1437788085	22:37,904,566	C/T	—	uncertain significance
rs200148764	22:37,904,575	C/T	—	risk factor
rs139006752	22:37,904,616	G/A	—	risk factor
rs149544125	22:37,904,618	C/T	—	likely benign
rs760532902	22:37,904,667	G/A	—	uncertain significance
rs201477949	22:37,904,676	G/A	—	uncertain significance
rs771502156	22:37,904,680	G/A	—	uncertain significance
rs56014332	22:37,904,695	A/G	—	benign
rs9610775	22:37,906,262	T/C	—	benign
rs2517815927	22:37,906,265	T/G	—	uncertain significance
rs897818107	22:37,906,274	G/C	—	uncertain significance
rs759878546	22:37,906,298	A/G	—	likely benign
rs576345404	22:37,906,300	A/G	—	likely benign
rs774120876	22:37,906,358	G/A	—	uncertain significance
rs150759948	22:37,906,400	C/T	—	uncertain significance
rs2092172	22:37,907,069	G/C	—	—
rs80184311	22:37,908,610	G/C	regulatory region variant	—
rs56385951	22:37,909,539	G/A	intron variant	—
rs1057519378	22:37,912,044	C/T	—	risk factor
rs1042147750	22:37,912,051	C/A	—	uncertain significance
rs374447215	22:37,912,114	G/A	—	uncertain significance
rs747136933	22:37,912,128	C/T	—	uncertain significance
rs200266181	22:37,912,217	C/T	—	likely benign
rs199764326	22:37,912,254	C/T	—	uncertain significance
rs760193849	22:37,912,291	C/G	—	uncertain significance
rs1397344151	22:37,914,073	T/C	—	uncertain significance
rs748053572	22:37,914,096	C/G	—	uncertain significance
rs772945473	22:37,914,112	C/T	—	uncertain significance
rs1295155383	22:37,915,037	G/C	—	uncertain significance
rs7287804	22:37,915,100	A/G	—	benign
rs2517825039	22:37,915,137	T/C	—	uncertain significance
rs79861380	22:37,915,145	C/T	—	benign
rs771224884	22:37,915,179	G/A	—	uncertain significance
rs777106332	22:37,915,187	C/A	—	likely benign

Gene information from NCBI Gene. Variant classifications from ClinVar.