CARD10
caspase recruitment domain family member 10
Summary
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]
Known Variants94 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2517793087 | 22:37,887,201 | G/T | — | uncertain significance |
| rs151290630 | 22:37,887,219 | C/T | — | benign |
| rs2517793119 | 22:37,887,224 | T/G | — | uncertain significance |
| rs768604345 | 22:37,887,237 | C/T | — | uncertain significance |
| rs200553561 | 22:37,887,241 | C/G | — | uncertain significance |
| rs753305136 | 22:37,887,277 | G/A | — | uncertain significance |
| rs1447230769 | 22:37,887,284 | C/G | — | likely benign |
| rs55875977 | 22:37,887,806 | G/A | — | benign |
| rs762662124 | 22:37,887,818 | C/G | — | uncertain significance |
| rs759948361 | 22:37,887,838 | G/A | — | uncertain significance |
| rs367817035 | 22:37,887,862 | G/T | — | uncertain significance |
| rs2517795752 | 22:37,888,540 | C/T | — | uncertain significance |
| rs377009692 | 22:37,888,769 | C/T | — | benign |
| rs2517796086 | 22:37,888,792 | T/C | — | uncertain significance |
| rs201794655 | 22:37,888,801 | G/A | — | risk factor |
| rs371884305 | 22:37,888,816 | C/G | — | likely benign |
| rs150625133 | 22:37,891,546 | C/T | — | uncertain significance |
| rs746726047 | 22:37,891,556 | G/A | — | uncertain significance |
| rs2517799347 | 22:37,891,788 | C/A | — | uncertain significance |
| rs141880624 | 22:37,891,841 | C/T | — | likely benign |
| rs143997223 | 22:37,891,957 | C/T | — | benign |
| rs148648878 | 22:37,891,958 | G/A | — | likely benign |
| rs1216184790 | 22:37,892,459 | T/G | — | uncertain significance |
| rs780670759 | 22:37,892,522 | C/T | — | uncertain significance |
| rs2517800347 | 22:37,892,537 | C/T | — | uncertain significance |
| rs942982585 | 22:37,893,060 | G/A | — | uncertain significance |
| rs1427102872 | 22:37,893,081 | G/A | — | uncertain significance |
| rs2517801194 | 22:37,893,105 | A/C | — | uncertain significance |
| rs201385412 | 22:37,893,107 | C/T | — | likely benign |
| rs201423754 | 22:37,893,171 | C/T | — | uncertain significance |
| rs562739778 | 22:37,893,172 | G/A | — | uncertain significance |
| rs1462313356 | 22:37,898,662 | C/A | — | uncertain significance |
| rs143277306 | 22:37,899,198 | T/C | — | uncertain significance |
| rs3817802 | 22:37,900,243 | G/A | — | benign |
| rs1273706151 | 22:37,900,254 | G/C | — | uncertain significance |
| rs3817803 | 22:37,900,276 | A/G | — | benign |
| rs61752257 | 22:37,900,286 | T/C | — | benign |
| rs773124059 | 22:37,900,662 | C/T | — | uncertain significance |
| rs768266973 | 22:37,900,677 | C/T | — | uncertain significance |
| rs150575230 | 22:37,900,720 | G/A | — | benign |
| rs755439574 | 22:37,900,734 | T/A | — | uncertain significance |
| rs3817805 | 22:37,900,762 | G/A | — | benign |
| rs3817806 | 22:37,900,771 | A/G | — | benign |
| rs144504964 | 22:37,900,772 | C/T | — | uncertain significance |
| rs370693557 | 22:37,902,192 | C/T | — | likely benign |
| rs374177056 | 22:37,902,193 | G/A | — | likely benign |
| rs760133266 | 22:37,902,215 | C/A | — | uncertain significance |
| rs61742320 | 22:37,902,235 | A/C | — | benign |
| rs145035525 | 22:37,902,274 | C/T | — | benign |
| rs201397783 | 22:37,902,275 | G/A | — | uncertain significance |
| rs372472560 | 22:37,902,311 | C/T | — | uncertain significance |
| rs748488870 | 22:37,902,324 | G/A | — | pathogenic |
| rs750643216 | 22:37,902,372 | G/A | — | risk factor |
| rs9619680 | 22:37,903,878 | A/G | — | benign |
| rs61746683 | 22:37,903,883 | C/T | — | benign |
| rs752695269 | 22:37,903,886 | T/C | — | uncertain significance |
| rs573923792 | 22:37,903,921 | G/A | — | uncertain significance |
| rs150236189 | 22:37,903,924 | C/T | — | uncertain significance |
| rs145143750 | 22:37,904,528 | A/C | — | benign |
| rs2517812717 | 22:37,904,544 | A/C | — | uncertain significance |
| rs1437788085 | 22:37,904,566 | C/T | — | uncertain significance |
| rs200148764 | 22:37,904,575 | C/T | — | risk factor |
| rs139006752 | 22:37,904,616 | G/A | — | risk factor |
| rs149544125 | 22:37,904,618 | C/T | — | likely benign |
| rs760532902 | 22:37,904,667 | G/A | — | uncertain significance |
| rs201477949 | 22:37,904,676 | G/A | — | uncertain significance |
| rs771502156 | 22:37,904,680 | G/A | — | uncertain significance |
| rs56014332 | 22:37,904,695 | A/G | — | benign |
| rs9610775 | 22:37,906,262 | T/C | — | benign |
| rs2517815927 | 22:37,906,265 | T/G | — | uncertain significance |
| rs897818107 | 22:37,906,274 | G/C | — | uncertain significance |
| rs759878546 | 22:37,906,298 | A/G | — | likely benign |
| rs576345404 | 22:37,906,300 | A/G | — | likely benign |
| rs774120876 | 22:37,906,358 | G/A | — | uncertain significance |
| rs150759948 | 22:37,906,400 | C/T | — | uncertain significance |
| rs2092172 | 22:37,907,069 | G/C | — | — |
| rs80184311 | 22:37,908,610 | G/C | regulatory region variant | — |
| rs56385951 | 22:37,909,539 | G/A | intron variant | — |
| rs1057519378 | 22:37,912,044 | C/T | — | risk factor |
| rs1042147750 | 22:37,912,051 | C/A | — | uncertain significance |
| rs374447215 | 22:37,912,114 | G/A | — | uncertain significance |
| rs747136933 | 22:37,912,128 | C/T | — | uncertain significance |
| rs200266181 | 22:37,912,217 | C/T | — | likely benign |
| rs199764326 | 22:37,912,254 | C/T | — | uncertain significance |
| rs760193849 | 22:37,912,291 | C/G | — | uncertain significance |
| rs1397344151 | 22:37,914,073 | T/C | — | uncertain significance |
| rs748053572 | 22:37,914,096 | C/G | — | uncertain significance |
| rs772945473 | 22:37,914,112 | C/T | — | uncertain significance |
| rs1295155383 | 22:37,915,037 | G/C | — | uncertain significance |
| rs7287804 | 22:37,915,100 | A/G | — | benign |
| rs2517825039 | 22:37,915,137 | T/C | — | uncertain significance |
| rs79861380 | 22:37,915,145 | C/T | — | benign |
| rs771224884 | 22:37,915,179 | G/A | — | uncertain significance |
| rs777106332 | 22:37,915,187 | C/A | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.