CCDC125
coiled-coil domain containing 125
Summary
Enables identical protein binding activity. Involved in activation of GTPase activity; negative regulation of Rho protein signal transduction; and negative regulation of cell motility. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants30 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs767411339 | 5:68,578,672 | T/C | — | uncertain significance |
| rs202230974 | 5:68,578,716 | C/A | — | uncertain significance |
| rs766137485 | 5:68,578,803 | C/T | — | uncertain significance |
| rs1181070415 | 5:68,578,818 | C/G | — | uncertain significance |
| rs4976187 | 5:68,579,947 | A/T | intron variant | — |
| rs528487517 | 5:68,581,262 | C/T | — | uncertain significance |
| rs1754571155 | 5:68,588,062 | T/A | — | uncertain significance |
| rs150476854 | 5:68,588,096 | G/C | — | uncertain significance |
| rs2532150070 | 5:68,588,107 | C/T | — | uncertain significance |
| rs11741775 | 5:68,590,395 | C/T | intron variant | — |
| rs11741826 | 5:68,590,400 | G/T | — | — |
| rs752089702 | 5:68,590,676 | A/G | — | uncertain significance |
| rs745493733 | 5:68,590,723 | G/A | — | uncertain significance |
| rs72767881 | 5:68,592,923 | C/T | intron variant | — |
| rs755608900 | 5:68,595,841 | C/G | — | uncertain significance |
| rs552118997 | 5:68,595,871 | T/C | — | uncertain significance |
| rs2532831866 | 5:68,602,694 | A/T | — | uncertain significance |
| rs1757598309 | 5:68,603,793 | G/C | — | likely benign |
| rs143088345 | 5:68,603,804 | T/C | — | likely benign |
| rs148239448 | 5:68,603,819 | C/T | — | uncertain significance |
| rs139810828 | 5:68,606,972 | C/G | — | uncertain significance |
| rs2533215380 | 5:68,609,813 | T/A | — | uncertain significance |
| rs11750525 | 5:68,610,438 | G/A | — | — |
| rs34449757 | 5:68,611,458 | G/C | — | — |
| rs66514959 | 5:68,611,583 | G/A | upstream gene variant | — |
| rs200011620 | 5:68,616,109 | G/A | — | uncertain significance |
| rs111417600 | 5:68,616,225 | G/A | — | uncertain significance |
| rs368303091 | 5:68,616,231 | T/A | — | uncertain significance |
| rs922343565 | 5:68,616,256 | C/T | — | uncertain significance |
| rs748564252 | 5:68,616,291 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.