CCL16
C-C motif chemokine ligand 16
Summary
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]
Known Variants9 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs33995560 | 17:34,303,771 | T/C | 3 prime UTR variant | — |
| rs751517629 | 17:34,304,630 | C/A | — | uncertain significance |
| rs1258056740 | 17:34,304,672 | G/C | — | likely benign |
| rs2544473686 | 17:34,304,756 | T/A | — | uncertain significance |
| rs752595378 | 17:34,304,763 | C/T | — | likely benign |
| rs2544474687 | 17:34,305,299 | T/C | — | uncertain significance |
| rs143283905 | 17:34,307,480 | T/C | downstream gene variant | — |
| rs142115594 | 17:34,308,444 | C/T | — | uncertain significance |
| rs73992652 | 17:34,309,703 | G/A | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.