CCL17
C-C motif chemokine ligand 17
Summary
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]
Known Variants11 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs223895 | 16:57,440,896 | T/C | intron variant | — |
| rs9302690 | 16:57,442,968 | G/C | — | — |
| rs223896 | 16:57,443,146 | G/T | — | — |
| rs223899 | 16:57,444,576 | T/A | — | — |
| rs223828 | 16:57,447,414 | T/C | regulatory region variant | — |
| rs532909387 | 16:57,447,890 | G/A | — | uncertain significance |
| rs61737346 | 16:57,449,006 | T/C | — | benign |
| rs377361646 | 16:57,449,014 | G/A | — | uncertain significance |
| rs372792230 | 16:57,449,041 | G/A | — | uncertain significance |
| rs2543522394 | 16:57,449,043 | G/A | — | uncertain significance |
| rs570762119 | 16:57,449,693 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.