CCL18
C-C motif chemokine ligand 18
Summary
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]
Known Variants6 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2015086 | 17:34,391,617 | A/G | upstream gene variant | — |
| rs2735835 | 17:34,393,296 | A/G | intron variant | — |
| rs2544576213 | 17:34,397,869 | A/G | — | likely benign |
| rs746913136 | 17:34,398,345 | G/A | — | likely benign |
| rs149506889 | 17:34,398,351 | A/G | — | uncertain significance |
| rs14304 | 17:34,398,495 | C/T | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.