CCL23
C-C motif chemokine ligand 23
Summary
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Known Variants21 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs761784343 | 17:34,340,259 | C/T | — | uncertain significance |
| rs527342285 | 17:34,340,269 | G/C | — | uncertain significance |
| rs2544538792 | 17:34,340,310 | G/A | — | uncertain significance |
| rs80219613 | 17:34,340,325 | C/T | missense variant | — |
| rs746038053 | 17:34,340,328 | C/G | — | uncertain significance |
| rs113634985 | 17:34,340,777 | C/T | splice region variant | — |
| rs777800056 | 17:34,340,793 | G/A | — | uncertain significance |
| rs2544539514 | 17:34,340,809 | T/C | — | uncertain significance |
| rs142522197 | 17:34,340,844 | G/A | — | uncertain significance |
| rs758235883 | 17:34,340,853 | C/T | — | uncertain significance |
| rs386352289 | 17:34,340,854 | G/A | — | uncertain significance |
| rs199911286 | 17:34,340,860 | T/C | — | uncertain significance |
| rs151273610 | 17:34,340,866 | A/G | — | uncertain significance |
| rs932976529 | 17:34,340,878 | C/T | — | uncertain significance |
| rs373678141 | 17:34,340,906 | A/T | — | uncertain significance |
| rs947326166 | 17:34,340,948 | C/T | — | uncertain significance |
| rs1845107384 | 17:34,341,386 | C/T | — | uncertain significance |
| rs771329185 | 17:34,341,422 | C/T | — | uncertain significance |
| rs192019333 | 17:34,343,097 | T/A | downstream gene variant | — |
| rs1291957979 | 17:34,344,919 | C/T | — | uncertain significance |
| rs116113790 | 17:34,345,309 | T/G | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.