CCL24
C-C motif chemokine ligand 24
Summary
This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. This protein also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. Finally, the protein is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2020]
Known Variants11 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1369446444 | 7:75,441,241 | T/C | — | uncertain significance |
| rs782346041 | 7:75,442,678 | C/A | — | uncertain significance |
| rs2485600525 | 7:75,443,003 | G/A | — | uncertain significance |
| rs873973 | 7:75,444,384 | C/G | — | — |
| rs4728493 | 7:75,446,974 | C/A | — | — |
| rs10272110 | 7:75,449,338 | T/C | — | — |
| rs35033400 | 7:75,449,341 | T/C | intron variant | — |
| rs188467150 | 7:75,451,528 | G/T | intron variant | — |
| rs147798273 | 7:75,452,921 | T/C | regulatory region variant | — |
| rs7811626 | 7:75,453,254 | G/A | — | — |
| rs145034849 | 7:75,453,626 | C/T | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.