CCL26
C-C motif chemokine ligand 26
Summary
This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. This protein also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2020]
Known Variants17 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2302009 | 7:75,398,998 | A/T | — | — |
| rs782135180 | 7:75,399,021 | T/G | — | uncertain significance |
| rs200493866 | 7:75,399,064 | T/C | — | likely benign |
| rs2302008 | 7:75,399,193 | C/T | intron variant | — |
| rs150951637 | 7:75,401,217 | G/A | — | uncertain significance |
| rs782045148 | 7:75,401,247 | A/C | — | uncertain significance |
| rs782727471 | 7:75,401,252 | C/T | — | likely benign |
| rs782124988 | 7:75,401,261 | G/A | — | uncertain significance |
| rs41463245 | 7:75,401,263 | C/T | stop gained | — |
| rs1258758306 | 7:75,401,278 | G/T | — | uncertain significance |
| rs1563334911 | 7:75,401,306 | G/A | — | uncertain significance |
| rs143820988 | 7:75,401,315 | C/A | — | uncertain significance |
| rs782615397 | 7:75,401,331 | A/G | — | likely benign |
| rs142338284 | 7:75,408,996 | G/A | regulatory region variant | — |
| rs533776305 | 7:75,413,022 | G/A | — | — |
| rs182743685 | 7:75,414,938 | T/G | intron variant | — |
| rs143011222 | 7:75,419,536 | T/C | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.