CCL5
C-C motif chemokine ligand 5
Summary
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Known Variants9 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1065341 | 17:34,198,593 | T/C | regulatory region variant | — |
| rs3817655 | 17:34,199,641 | A/G | — | — |
| rs41471045 | 17:34,202,994 | A/G | regulatory region variant | — |
| rs138511589 | 17:34,205,601 | C/T | — | uncertain significance |
| rs759918234 | 17:34,205,632 | T/C | — | uncertain significance |
| rs2280789 | 17:34,207,003 | A/G | regulatory region variant | pathogenic |
| rs571565063 | 17:34,207,296 | G/A | — | likely benign |
| rs2280788 | 17:34,207,405 | G/C | regulatory region variant | pathogenic |
| rs2107538 | 17:34,207,780 | C/T | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.