CD37
CD37 molecule
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Known Variants12 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs565570635 | 19:49,838,341 | G/A | — | — |
| rs75218499 | 19:49,839,033 | G/C | — | benign |
| rs1334090983 | 19:49,840,196 | C/A | — | uncertain significance |
| rs138165790 | 19:49,840,207 | G/A | missense variant | — |
| rs377403465 | 19:49,841,203 | G/A | — | benign |
| rs370552650 | 19:49,841,206 | G/T | — | uncertain significance |
| rs2514517711 | 19:49,842,017 | A/G | — | uncertain significance |
| rs377693977 | 19:49,842,147 | G/A | — | likely benign |
| rs73588388 | 19:49,842,580 | C/T | — | benign |
| rs202130474 | 19:49,842,642 | G/T | — | uncertain significance |
| rs751006342 | 19:49,843,564 | C/A | — | uncertain significance |
| rs748060068 | 19:49,843,580 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.