CD70
CD70 molecule
Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
Known Variants27 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs142340418 | 19:6,583,330 | T/C | — | likely benign |
| rs111613514 | 19:6,583,485 | A/C | — | likely benign |
| rs111956974 | 19:6,584,792 | G/A | downstream gene variant | — |
| rs182050995 | 19:6,586,039 | G/T | — | uncertain significance |
| rs368303189 | 19:6,586,078 | G/A | — | pathogenic |
| rs2512811392 | 19:6,586,102 | G/A | — | uncertain significance |
| rs781260683 | 19:6,586,116 | G/A | — | uncertain significance |
| rs778323980 | 19:6,586,136 | C/T | — | likely benign |
| rs1394445954 | 19:6,586,164 | C/A | — | uncertain significance |
| rs34080876 | 19:6,586,190 | G/A | — | likely benign |
| rs548095306 | 19:6,586,225 | C/T | — | uncertain significance |
| rs141875251 | 19:6,586,260 | G/A | — | uncertain significance |
| rs145060542 | 19:6,586,261 | T/C | — | uncertain significance |
| rs1862511 | 19:6,586,268 | G/A | — | benign |
| rs141989071 | 19:6,586,323 | C/T | — | uncertain significance |
| rs2512811970 | 19:6,586,353 | T/C | — | likely benign |
| rs774636584 | 19:6,586,398 | C/T | — | uncertain significance |
| rs16994592 | 19:6,586,498 | T/C | intron variant | — |
| rs190563913 | 19:6,588,661 | C/G | — | — |
| rs75041397 | 19:6,588,903 | G/A | regulatory region variant | — |
| rs555945239 | 19:6,590,107 | G/C | — | likely benign |
| rs344589 | 19:6,590,789 | A/G | — | benign |
| rs148772362 | 19:6,590,911 | C/T | — | uncertain significance |
| rs780084590 | 19:6,590,941 | G/T | — | uncertain significance |
| rs145065586 | 19:6,590,966 | C/T | — | likely benign |
| rs776250575 | 19:6,590,988 | G/A | — | uncertain significance |
| rs17703895 | 19:6,591,146 | C/A | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.