CDC5L

cell division cycle 5 like

Summary

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]

Known Variants66 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs77690047	6:44,355,228	A/C	—	benign
rs2297334	6:44,355,399	G/T	—	benign
rs2297333	6:44,355,423	C/T	—	benign
rs144524558	6:44,355,554	C/T	—	likely benign
rs150971616	6:44,355,559	A/G	—	likely benign
rs2297332	6:44,355,682	G/A	—	benign
rs2297331	6:44,355,699	T/C	—	benign
rs6908640	6:44,357,884	T/G	—	benign
rs11571911	6:44,358,025	G/A	—	likely benign
rs1016731902	6:44,358,106	A/G	—	uncertain significance
rs9369481	6:44,358,444	T/G	—	benign
rs7757621	6:44,360,155	T/A	—	benign
rs778384309	6:44,360,465	C/G	—	uncertain significance
rs556847454	6:44,360,491	A/G	—	likely benign
rs10948136	6:44,360,533	A/G	—	benign
rs6942323	6:44,360,680	G/A	—	benign
rs372141515	6:44,361,295	A/G	—	uncertain significance
rs36064417	6:44,361,309	G/A	—	benign
rs2534991425	6:44,364,083	C/T	—	uncertain significance
rs373544801	6:44,364,164	T/C	—	likely benign
rs2535016484	6:44,371,592	A/T	—	uncertain significance
rs1791245673	6:44,371,611	G/A	—	uncertain significance
rs549734666	6:44,371,656	A/C	—	uncertain significance
rs1561969930	6:44,371,704	A/G	—	uncertain significance
rs6934058	6:44,371,714	C/T	—	benign
rs79843509	6:44,374,056	A/G	—	benign
rs534942880	6:44,374,076	G/A	—	uncertain significance
rs1952980	6:44,374,467	A/G	—	benign
rs1952979	6:44,374,508	G/A	—	benign
rs6458384	6:44,375,919	T/C	—	benign
rs377117589	6:44,376,171	G/A	—	likely benign
rs141567880	6:44,376,192	A/G	—	benign
rs200087867	6:44,376,206	T/C	—	likely benign
rs376004864	6:44,376,302	A/G	—	uncertain significance
rs144752067	6:44,387,233	A/G	—	likely benign
rs6923521	6:44,387,517	C/G	—	benign
rs9395016	6:44,387,590	C/A	—	benign
rs747924598	6:44,390,419	G/A	—	uncertain significance
rs151023284	6:44,390,458	C/T	—	uncertain significance
rs768966403	6:44,390,476	G/C	—	uncertain significance
rs1298525575	6:44,390,516	C/G	—	uncertain significance
rs11572006	6:44,390,518	A/G	—	benign
rs11572007	6:44,390,764	G/T	—	benign
rs11572012	6:44,392,016	A/C	—	benign
rs548309345	6:44,392,251	G/A	—	likely benign
rs762774387	6:44,392,299	T/C	—	likely benign
rs145762260	6:44,392,313	G/A	—	uncertain significance
rs864127	6:44,392,514	G/A	—	benign
rs11572020	6:44,393,635	G/A	—	benign
rs1055398152	6:44,393,857	G/T	—	uncertain significance
rs2532512495	6:44,394,313	T/G	—	uncertain significance
rs368161524	6:44,394,370	A/G	—	uncertain significance
rs777791487	6:44,394,421	A/C	—	uncertain significance
rs11572023	6:44,394,422	T/C	—	benign
rs4714787	6:44,397,281	G/C	—	benign
rs2532523848	6:44,397,502	A/T	—	uncertain significance
rs80152853	6:44,397,882	T/C	—	benign
rs1293208	6:44,406,908	A/T	—	—
rs11572048	6:44,413,460	G/C	—	benign
rs2273666	6:44,413,463	T/A	—	benign
rs1296778518	6:44,413,480	G/A	—	uncertain significance
rs142471993	6:44,413,525	T/C	—	uncertain significance
rs755120249	6:44,413,536	C/T	—	likely benign
rs1295835040	6:44,413,548	C/T	—	uncertain significance
rs202064406	6:44,413,549	G/A	—	uncertain significance
rs2273667	6:44,413,736	A/G	—	benign

Gene information from NCBI Gene. Variant classifications from ClinVar.