CDCA4

cell division cycle associated 4

Summary

This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, May 2014]

Known Variants20 total

rsidPosition (GRCh37)AllelesClassClinVar
rs15045169414:105,477,582C/G—uncertain significance
rs119107080814:105,477,635T/C—uncertain significance
rs137046816314:105,477,641C/T—uncertain significance
rs74569833914:105,477,645C/T—uncertain significance
rs53335973014:105,477,834C/G—uncertain significance
rs13932629014:105,477,863G/A—uncertain significance
rs254270305114:105,477,933G/A—uncertain significance
rs75486516014:105,477,959C/T—uncertain significance
rs254270320314:105,477,969T/A—uncertain significance
rs14796589114:105,478,002G/A—uncertain significance
rs75256484114:105,478,028C/A—uncertain significance
rs76287416214:105,478,029G/A—uncertain significance
rs20145246514:105,478,034G/A—uncertain significance
rs37556154914:105,478,046G/A—uncertain significance
rs20080080414:105,478,149T/A—uncertain significance
rs147287314714:105,478,158G/C—uncertain significance
rs116396086614:105,478,162C/G—uncertain significance
rs14531895314:105,478,166C/T—uncertain significance
rs76875403814:105,478,200C/T—uncertain significance
rs407508514:105,479,541T/C——

Gene information from NCBI Gene. Variant classifications from ClinVar.