CEACAM6
CEA cell adhesion molecule 6
Summary
This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
Known Variants26 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs770162662 | 19:42,259,381 | G/T | — | — |
| rs199578274 | 19:42,259,592 | A/G | — | uncertain significance |
| rs2513449464 | 19:42,259,596 | A/T | — | uncertain significance |
| rs149583724 | 19:42,260,565 | C/T | — | uncertain significance |
| rs61736638 | 19:42,260,697 | G/A | — | benign |
| rs374616817 | 19:42,260,718 | G/T | — | uncertain significance |
| rs781957174 | 19:42,260,750 | C/A | — | uncertain significance |
| rs782391374 | 19:42,260,760 | C/T | — | uncertain significance |
| rs570434430 | 19:42,260,777 | G/A | — | uncertain significance |
| rs140710603 | 19:42,260,814 | T/C | — | uncertain significance |
| rs143835773 | 19:42,260,831 | G/C | — | uncertain significance |
| rs782398702 | 19:42,260,844 | C/T | — | uncertain significance |
| rs782483457 | 19:42,265,157 | C/T | — | uncertain significance |
| rs2513456458 | 19:42,265,161 | G/C | — | uncertain significance |
| rs139700050 | 19:42,265,219 | G/A | — | uncertain significance |
| rs373281695 | 19:42,265,267 | T/A | — | uncertain significance |
| rs373480488 | 19:42,265,307 | A/T | — | uncertain significance |
| rs369021656 | 19:42,265,345 | G/A | — | uncertain significance |
| rs143709500 | 19:42,265,357 | G/A | — | uncertain significance |
| rs782389697 | 19:42,265,381 | A/G | — | uncertain significance |
| rs782220668 | 19:42,265,394 | C/T | — | likely benign |
| rs782634538 | 19:42,265,921 | C/T | — | uncertain significance |
| rs7246116 | 19:42,265,953 | C/T | — | benign |
| rs146841517 | 19:42,265,976 | A/T | — | uncertain significance |
| rs368722735 | 19:42,266,056 | G/A | — | uncertain significance |
| rs879945992 | 19:42,270,123 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.