CENPE

centromere protein E

Summary

Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Nov 2014]

Known Variants338 total

rsidPosition (GRCh37)AllelesClassClinVar
rs617562934:104,027,405C/T—conflicting classifications of pathogenicity
rs7718329734:104,027,436C/T—likely benign
rs24772042114:104,027,444C/G—uncertain significance
rs172158624:104,027,644G/A—benign
rs726650484:104,029,739G/C—benign
rs12497548854:104,029,963G/A—uncertain significance
rs7691389614:104,029,995C/T—uncertain significance
rs9661269064:104,030,012T/C—likely benign
rs7775876924:104,030,053G/A—uncertain significance
rs1413211144:104,030,085C/T—conflicting classifications of pathogenicity
rs1450486324:104,030,087T/G—uncertain significance
rs14305970474:104,030,144A/C—likely benign
rs7569313284:104,030,150C/T—likely benign
rs5768751644:104,030,198G/C—likely benign
rs617583724:104,030,207C/T—likely benign
rs1495329164:104,030,239G/C—uncertain significance
rs769732524:104,030,393A/C—likely benign
rs1889910384:104,031,969T/C—likely benign
rs13430817024:104,032,063T/A—uncertain significance
rs13055400724:104,032,082G/T—uncertain significance
rs7564836434:104,032,106C/T—uncertain significance
rs1485824474:104,032,107G/A—likely benign
rs24773020894:104,032,116T/A—likely benign
rs14440274414:104,032,153G/T—uncertain significance
rs11619345434:104,032,156T/A—uncertain significance
rs12598901614:104,032,158T/C—likely benign
rs1429390204:104,032,167C/T—likely benign
rs27204494:104,032,264G/A—benign
rs803398684:104,037,519T/C—likely benign
rs12354536644:104,037,740T/C—uncertain significance
rs7811100464:104,037,787C/T—likely benign
rs7456552664:104,037,795T/G—uncertain significance
rs2005635044:104,037,806A/G—uncertain significance
rs17501397794:104,037,807T/A—uncertain significance
rs27204534:104,041,293T/C—benign
rs1425185654:104,041,340G/A—uncertain significance
rs1406306844:104,041,412G/T—likely benign
rs7744720494:104,041,429C/T—uncertain significance
rs7620685814:104,041,432T/C—uncertain significance
rs7675451044:104,041,439G/A—uncertain significance
rs12749895454:104,041,442T/C—uncertain significance
rs3693377354:104,041,447C/T—uncertain significance
rs11956867004:104,041,461A/C—uncertain significance
rs3713819154:104,041,462T/C—likely benign
rs1167186244:104,041,673T/G—likely benign
rs14824818954:104,044,075T/C—uncertain significance
rs7472004934:104,044,121C/A—uncertain significance
rs3739652114:104,044,186C/G—uncertain significance
rs617515924:104,044,197G/C—likely benign
rs1112816004:104,044,243T/C—conflicting classifications of pathogenicity
rs1124418544:104,044,283G/A—likely benign
rs1132448794:104,044,478C/T—likely benign
rs125073484:104,044,529C/T—benign
rs1413543414:104,053,867A/T—likely benign
rs1450824104:104,053,907G/T—likely benign
rs17517002314:104,053,916T/G—uncertain significance
rs5443268304:104,053,939G/A—uncertain significance
rs1388822124:104,053,957C/T—uncertain significance
rs1902256594:104,053,976T/C—benign
rs7520639904:104,053,995T/C—uncertain significance
rs12469641154:104,054,058G/A—likely benign
rs27204604:104,054,686A/Gintron variantbenign
rs5542142254:104,054,908G/C—uncertain significance
rs1122127024:104,054,927A/C—likely benign
rs12142091864:104,054,937A/G—uncertain significance
rs24777722684:104,055,007C/T—uncertain significance
rs588554534:104,055,246C/T—likely benign
rs26230624:104,057,121C/T—benign
rs27204634:104,057,248G/A—benign
rs7598272604:104,057,332G/A—uncertain significance
rs24778200514:104,057,358T/G—uncertain significance
rs7654565834:104,057,364A/G—likely benign
rs1418131704:104,057,383T/C—conflicting classifications of pathogenicity
rs3720966664:104,057,385G/C—likely benign
rs7784696564:104,057,420G/A—uncertain significance
rs7714707574:104,057,443T/A—uncertain significance
rs3679080704:104,057,464C/T—uncertain significance
rs750776514:104,059,213C/T—likely benign
rs117280634:104,059,283A/G—likely benign
rs729461394:104,059,360C/T—likely benign
rs22436824:104,059,542G/A—benign
rs1388873574:104,059,571C/T—likely benign
rs68307914:104,059,823A/G—benign
rs1162401574:104,060,681A/T—benign
rs28666334:104,060,781C/T—benign
rs1489697104:104,060,947C/G—conflicting classifications of pathogenicity
rs7546281224:104,060,952T/C—uncertain significance
rs7678529094:104,060,968G/C—uncertain significance
rs7611378924:104,060,985C/T—likely benign
rs7775853614:104,061,073T/C—uncertain significance
rs5536146054:104,061,079G/A—uncertain significance
rs10043495164:104,061,080T/A—uncertain significance
rs24778948374:104,061,086G/C—uncertain significance
rs3694155524:104,061,155T/C—uncertain significance
rs617515934:104,061,156T/C—benign
rs76861054:104,061,266G/A—benign
rs76640214:104,061,351T/C—benign
rs1149549394:104,061,383C/A—benign
rs3777069874:104,061,447T/A—uncertain significance
rs358621234:104,061,452T/C—likely benign

Showing 100 of 338 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.