CENPO

centromere protein O

Summary

This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Known Variants18 total

rsidPosition (GRCh37)AllelesClassClinVar
rs46657202:25,018,256T/A
rs2007224852:25,022,588T/Auncertain significance
rs1437829862:25,022,591C/Tuncertain significance
rs7485923162:25,022,666C/Tuncertain significance
rs2019200352:25,022,667G/Alikely benign
rs12305442482:25,022,678G/Alikely benign
rs7672289712:25,022,690G/Auncertain significance
rs5646214852:25,022,697G/Auncertain significance
rs1998340292:25,022,711A/Clikely benign
rs118950262:25,036,858C/T
rs24664464912:25,038,387G/Tuncertain significance
rs9560999302:25,038,388C/Auncertain significance
rs1490239802:25,038,473C/Tuncertain significance
rs7628005772:25,039,674G/Auncertain significance
rs1394639302:25,040,541G/Tuncertain significance
rs13458720962:25,040,608C/Guncertain significance
rs7458184612:25,040,626C/Tuncertain significance
rs24664662002:25,040,648A/Cuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.