CGAS
cyclic GMP-AMP synthase
Summary
Enables several functions, including 2',3'-cyclic GMP-AMP synthase activity; molecular condensate scaffold activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including intracellular signal transduction; paracrine signaling; and regulation of defense response. Located in nuclear body; plasma membrane; and site of double-strand break. Is active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants36 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs311678 | 6:74,135,016 | C/A | missense variant | — |
| rs1165928919 | 6:74,135,054 | T/A | — | uncertain significance |
| rs767651417 | 6:74,135,063 | G/C | — | uncertain significance |
| rs968744350 | 6:74,135,149 | C/T | — | uncertain significance |
| rs1031745357 | 6:74,135,150 | G/A | — | uncertain significance |
| rs148298509 | 6:74,135,209 | T/C | — | uncertain significance |
| rs141390590 | 6:74,135,220 | G/T | — | uncertain significance |
| rs146116825 | 6:74,138,471 | G/C | — | uncertain significance |
| rs370272118 | 6:74,138,502 | C/T | — | uncertain significance |
| rs531954415 | 6:74,138,522 | C/T | — | uncertain significance |
| rs190867294 | 6:74,150,030 | C/T | — | uncertain significance |
| rs182033096 | 6:74,153,673 | C/G | intron variant | — |
| rs2150815939 | 6:74,155,313 | G/A | — | uncertain significance |
| rs610913 | 6:74,155,346 | G/A | missense variant | — |
| rs2533208862 | 6:74,155,365 | T/C | — | uncertain significance |
| rs751844640 | 6:74,155,388 | G/T | — | uncertain significance |
| rs755839580 | 6:74,155,391 | C/T | — | uncertain significance |
| rs2533216067 | 6:74,161,292 | C/T | — | uncertain significance |
| rs141016543 | 6:74,161,405 | G/A | — | uncertain significance |
| rs150220319 | 6:74,161,406 | C/G | — | uncertain significance |
| rs370001875 | 6:74,161,408 | C/T | — | uncertain significance |
| rs754251787 | 6:74,161,441 | C/G | — | uncertain significance |
| rs1451835720 | 6:74,161,442 | G/A | — | uncertain significance |
| rs1319608405 | 6:74,161,485 | G/T | — | likely benign |
| rs757628777 | 6:74,161,495 | C/T | — | uncertain significance |
| rs527795978 | 6:74,161,511 | G/C | — | uncertain significance |
| rs1015622683 | 6:74,161,589 | C/T | — | uncertain significance |
| rs200213844 | 6:74,161,664 | C/T | — | uncertain significance |
| rs572861541 | 6:74,161,718 | T/G | — | uncertain significance |
| rs1194601988 | 6:74,161,727 | G/A | — | uncertain significance |
| rs769976348 | 6:74,161,745 | C/A | — | uncertain significance |
| rs766912294 | 6:74,161,763 | C/A | — | uncertain significance |
| rs901219481 | 6:74,161,781 | C/T | — | uncertain significance |
| rs760649119 | 6:74,161,835 | C/A | — | uncertain significance |
| rs147035222 | 6:74,161,855 | G/C | — | conflicting classifications of pathogenicity |
| rs774733961 | 6:74,161,897 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.