CGB5

chorionic gonadotropin subunit beta 5

Summary

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

Known Variants15 total

rsidPosition (GRCh37)AllelesClassClinVar
rs726000219:49,545,872A/Gcoding sequence variant
rs19972000919:49,547,883A/Glikely benign
rs6212604819:49,547,890G/Abenign
rs140805756219:49,547,895G/Auncertain significance
rs20137322119:49,547,907G/Auncertain significance
rs122231752319:49,547,963G/Auncertain significance
rs146913866219:49,548,000T/Guncertain significance
rs251382478319:49,548,280T/Cuncertain significance
rs77676947019:49,548,325G/Tuncertain significance
rs3567953819:49,548,359C/Tlikely benign
rs101745988819:49,548,449C/Guncertain significance
rs75191566619:49,548,468T/Cuncertain significance
rs120310223519:49,548,481C/Guncertain significance
rs77709319219:49,548,489C/Guncertain significance
rs74563789319:49,548,494C/Guncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.