CGB8
chorionic gonadotropin subunit beta 8
Summary
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
Known Variants24 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs758253561 | 19:49,550,928 | G/C | — | uncertain significance |
| rs71352726 | 19:49,550,960 | A/T | — | uncertain significance |
| rs1214273774 | 19:49,550,997 | G/A | — | uncertain significance |
| rs761108717 | 19:49,551,009 | C/G | — | uncertain significance |
| rs915158482 | 19:49,551,036 | T/A | — | uncertain significance |
| rs2513827515 | 19:49,551,054 | T/G | — | uncertain significance |
| rs1408268108 | 19:49,551,085 | G/C | — | uncertain significance |
| rs1354221277 | 19:49,551,124 | C/A | — | uncertain significance |
| rs1259097854 | 19:49,551,129 | C/T | — | uncertain significance |
| rs879871530 | 19:49,551,132 | G/A | — | uncertain significance |
| rs927750169 | 19:49,551,171 | C/T | — | uncertain significance |
| rs1414372486 | 19:49,551,177 | T/G | — | likely benign |
| rs1338439169 | 19:49,551,187 | C/T | — | uncertain significance |
| rs1199499010 | 19:49,551,210 | C/G | — | likely benign |
| rs1368576109 | 19:49,551,220 | C/T | — | uncertain significance |
| rs1463964361 | 19:49,551,464 | T/C | — | uncertain significance |
| rs1375512783 | 19:49,551,562 | C/T | — | uncertain significance |
| rs1252727580 | 19:49,551,568 | C/T | — | uncertain significance |
| rs3956248 | 19:49,551,574 | G/A | — | uncertain significance |
| rs2513828142 | 19:49,551,604 | C/T | — | uncertain significance |
| rs200252416 | 19:49,551,628 | C/T | — | uncertain significance |
| rs375079954 | 19:49,551,987 | A/C | — | uncertain significance |
| rs543985594 | 19:49,551,989 | A/G | — | uncertain significance |
| rs28553919 | 19:49,553,380 | A/C | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.