CIAO3

cytosolic iron-sulfur assembly component 3

Summary

Predicted to enable 4 iron, 4 sulfur cluster binding activity and metal ion binding activity. Involved in several processes, including intracellular oxygen homeostasis; iron-sulfur cluster assembly; and response to hypoxia. Part of cytosolic [4Fe-4S] assembly targeting complex. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants39 total

rsidPosition (GRCh37)AllelesClassClinVar
rs20135665616:780,425G/Auncertain significance
rs37646952416:780,439G/Clikely benign
rs77135238716:780,446C/Tuncertain significance
rs76527709716:780,469G/Auncertain significance
rs130926928116:780,493T/Cuncertain significance
rs3485151516:780,510C/Tbenign
rs14480261616:780,545C/Tlikely benign
rs13799477016:780,575C/Tlikely benign
rs11462027416:780,664G/Abenign
rs77714156316:780,885G/Auncertain significance
rs14335648016:780,890C/Tuncertain significance
rs75041977716:780,923C/Tuncertain significance
rs53067248116:781,620C/Tuncertain significance
rs37270652116:781,626G/Auncertain significance
rs116921494216:781,652G/Auncertain significance
rs95673249416:781,665G/Auncertain significance
rs128025474916:781,695C/Tlikely benign
rs129757299216:783,310C/Tuncertain significance
rs78093334916:783,342T/Clikely benign
rs14412477416:783,400C/Tuncertain significance
rs1205124516:783,865T/Cregulatory region variant
rs18271601316:784,220C/Tlikely benign
rs14080091016:784,255C/Guncertain significance
rs78007513116:784,284C/Tuncertain significance
rs13825825216:784,800G/Auncertain significance
rs74825631716:784,811C/Tuncertain significance
rs14987709216:786,326G/Auncertain significance
rs20191007716:787,218C/Tlikely benign
rs75530474116:787,257T/Auncertain significance
rs76087134016:787,266C/Tuncertain significance
rs37696604616:787,284C/Tuncertain significance
rs119954091016:789,665C/Guncertain significance
rs76617034116:789,680C/Tlikely benign
rs804585016:789,693C/Tbenign
rs254419730416:790,928G/Cuncertain significance
rs77189358216:790,934T/Auncertain significance
rs96970071616:790,964C/Tuncertain significance
rs74724041016:790,983C/Auncertain significance
rs1164879616:792,190A/Gupstream gene variant

Gene information from NCBI Gene. Variant classifications from ClinVar.