CLASP1

cytoplasmic linker associated protein 1

Summary

CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]

Known Variants75 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs200795859	2:122,098,435	C/T	—	likely benign
rs765577807	2:122,120,819	C/T	—	uncertain significance
rs755594869	2:122,120,857	G/A	—	uncertain significance
rs747188884	2:122,122,740	C/T	—	uncertain significance
rs1344204517	2:122,122,803	T/C	—	uncertain significance
rs781422549	2:122,122,858	G/A	—	uncertain significance
rs2304662	2:122,122,956	C/T	intron variant	—
rs116176232	2:122,125,213	G/A	—	benign
rs553380975	2:122,125,252	C/T	—	likely benign
rs376007044	2:122,125,253	G/A	—	likely benign
rs369126224	2:122,125,331	G/A	—	uncertain significance
rs755382948	2:122,125,338	G/A	—	uncertain significance
rs377065133	2:122,125,362	C/G	—	uncertain significance
rs144957722	2:122,125,373	G/T	—	benign
rs2070540102	2:122,135,109	G/T	—	uncertain significance
rs2467663301	2:122,135,127	T/A	—	uncertain significance
rs754458736	2:122,135,160	G/A	—	uncertain significance
rs752571395	2:122,135,169	C/T	—	uncertain significance
rs371184633	2:122,139,876	G/A	—	likely benign
rs2071888101	2:122,139,893	A/G	—	uncertain significance
rs1286842610	2:122,139,899	G/A	—	uncertain significance
rs768466565	2:122,144,779	C/T	—	uncertain significance
rs374774647	2:122,145,442	G/C	—	uncertain significance
rs2468008449	2:122,154,736	T/C	—	uncertain significance
rs2468009473	2:122,154,792	T/C	—	uncertain significance
rs781105177	2:122,159,110	C/T	—	uncertain significance
rs1190247317	2:122,165,073	G/C	—	uncertain significance
rs1232933431	2:122,165,171	G/C	—	uncertain significance
rs775582460	2:122,165,178	G/A	—	likely benign
rs751335906	2:122,168,473	G/A	—	uncertain significance
rs2468233727	2:122,168,486	G/T	—	uncertain significance
rs2468344286	2:122,176,274	C/T	—	uncertain significance
rs186502681	2:122,176,275	A/G	—	likely benign
rs200744541	2:122,176,303	G/A	—	uncertain significance
rs149355721	2:122,182,791	C/T	—	benign
rs958220718	2:122,182,802	G/A	—	uncertain significance
rs771685570	2:122,182,810	C/T	—	uncertain significance
rs377056109	2:122,182,834	C/T	—	uncertain significance
rs985638837	2:122,182,844	T/C	—	uncertain significance
rs370837663	2:122,187,676	G/A	—	uncertain significance
rs368747816	2:122,187,711	T/C	—	uncertain significance
rs532629050	2:122,187,735	C/T	—	uncertain significance
rs200838170	2:122,205,075	C/T	—	uncertain significance
rs17006477	2:122,205,590	G/A	intron variant	—
rs2468884796	2:122,206,583	A/G	—	uncertain significance
rs368848404	2:122,206,587	T/C	—	uncertain significance
rs374803325	2:122,206,618	T/C	—	likely benign
rs2304560	2:122,216,419	A/G	—	benign
rs368563172	2:122,216,428	C/T	—	likely benign
rs2087259212	2:122,216,490	T/G	—	uncertain significance
rs1313640412	2:122,217,658	T/C	—	uncertain significance
rs150204660	2:122,227,455	C/G	—	benign
rs2090367660	2:122,227,503	C/T	—	uncertain significance
rs770261375	2:122,260,763	T/C	—	uncertain significance
rs574686823	2:122,273,247	T/A	—	uncertain significance
rs199865832	2:122,286,263	G/A	—	uncertain significance
rs765658534	2:122,286,291	G/C	—	uncertain significance
rs2470253839	2:122,286,293	G/A	—	uncertain significance
rs376053483	2:122,288,449	C/G	—	likely benign
rs370715569	2:122,288,463	C/G	coding sequence variant	pathogenic
rs559979281	2:122,288,468	C/G	coding sequence variant	pathogenic
rs750325275	2:122,288,471	G/A	coding sequence variant	pathogenic
rs374299350	2:122,288,485	G/A	coding sequence variant	pathogenic
rs771577373	2:122,288,490	A/C	—	likely pathogenic
rs756026847	2:122,288,492	G/A	coding sequence variant	pathogenic
rs863225422	2:122,288,503	G/A	coding sequence variant	pathogenic
rs181195449	2:122,288,505	G/A	coding sequence variant	pathogenic
rs188343279	2:122,288,506	G/A	coding sequence variant	pathogenic
rs180755563	2:122,288,508	C/T	coding sequence variant	pathogenic
rs575472572	2:122,288,510	G/C	coding sequence variant	uncertain significance
rs377619732	2:122,288,521	G/C	coding sequence variant	pathogenic
rs763500364	2:122,288,566	G/A	coding sequence variant	pathogenic
rs863225423	2:122,288,573	T/C	coding sequence variant	pathogenic
rs544312701	2:122,288,579	G/A	coding sequence variant	pathogenic
rs2064345894	2:122,363,292	G/T	—	uncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.