CLASP2
cytoplasmic linker associated protein 2
Summary
Enables cytoskeletal protein binding activity; dystroglycan binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including cytoskeleton organization; positive regulation of extracellular matrix organization; and regulation of supramolecular fiber organization. Located in several cellular components, including basal cortex; focal adhesion; and microtubule cytoskeleton. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants72 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs765282276 | 3:33,540,158 | C/G | — | uncertain significance |
| rs111990025 | 3:33,543,195 | C/T | — | benign |
| rs867925729 | 3:33,543,252 | A/G | — | likely benign |
| rs769741856 | 3:33,552,110 | C/T | — | likely benign |
| rs1406793687 | 3:33,552,147 | T/A | — | uncertain significance |
| rs953040113 | 3:33,552,159 | T/C | — | uncertain significance |
| rs2472030745 | 3:33,552,226 | C/G | — | uncertain significance |
| rs748075075 | 3:33,558,540 | A/C | — | uncertain significance |
| rs183373873 | 3:33,558,573 | T/C | — | benign |
| rs551664425 | 3:33,576,726 | G/A | — | likely benign |
| rs750046209 | 3:33,576,829 | G/A | — | uncertain significance |
| rs746484508 | 3:33,576,832 | C/T | — | uncertain significance |
| rs370607793 | 3:33,576,835 | G/A | — | uncertain significance |
| rs767746519 | 3:33,576,884 | G/A | — | uncertain significance |
| rs368146012 | 3:33,576,936 | C/T | — | likely benign |
| rs762622458 | 3:33,580,289 | C/T | — | uncertain significance |
| rs766242563 | 3:33,580,290 | A/C | — | uncertain significance |
| rs2474154677 | 3:33,580,331 | C/T | — | uncertain significance |
| rs376323807 | 3:33,580,342 | C/T | — | uncertain significance |
| rs9815692 | 3:33,582,874 | A/T | intron variant | — |
| rs377121956 | 3:33,584,948 | T/C | — | likely benign |
| rs187113660 | 3:33,585,009 | G/A | — | benign |
| rs781471511 | 3:33,586,207 | T/C | — | uncertain significance |
| rs769385672 | 3:33,586,311 | G/A | — | uncertain significance |
| rs774785600 | 3:33,586,323 | G/A | — | uncertain significance |
| rs58525675 | 3:33,596,069 | C/T | upstream gene variant | — |
| rs1055374428 | 3:33,600,846 | T/C | — | uncertain significance |
| rs111401421 | 3:33,611,491 | C/T | intron variant | — |
| rs2477848647 | 3:33,614,666 | A/T | — | uncertain significance |
| rs375259194 | 3:33,614,685 | A/G | — | likely benign |
| rs2477868352 | 3:33,614,780 | C/T | — | uncertain significance |
| rs2478081136 | 3:33,615,983 | T/G | — | uncertain significance |
| rs575359833 | 3:33,615,993 | G/C | — | benign |
| rs753074704 | 3:33,623,328 | A/G | — | uncertain significance |
| rs1280569643 | 3:33,623,424 | G/C | — | uncertain significance |
| rs780874039 | 3:33,633,928 | G/A | — | uncertain significance |
| rs189919699 | 3:33,636,469 | G/A | — | benign |
| rs376410378 | 3:33,644,455 | T/C | — | uncertain significance |
| rs779980704 | 3:33,644,477 | C/T | — | uncertain significance |
| rs199696785 | 3:33,644,497 | C/T | — | likely benign |
| rs2072729519 | 3:33,644,549 | C/G | — | uncertain significance |
| rs375252014 | 3:33,644,568 | A/G | — | benign |
| rs61734242 | 3:33,648,145 | A/G | — | benign |
| rs550156050 | 3:33,648,902 | G/A | — | likely benign |
| rs370720523 | 3:33,648,943 | C/T | — | uncertain significance |
| rs752250877 | 3:33,650,074 | G/C | — | uncertain significance |
| rs558837241 | 3:33,650,084 | C/T | — | uncertain significance |
| rs553022786 | 3:33,652,360 | T/C | — | — |
| rs142035502 | 3:33,653,540 | T/A | — | likely benign |
| rs2082000526 | 3:33,686,291 | T/C | — | uncertain significance |
| rs1465420591 | 3:33,686,373 | T/G | — | uncertain significance |
| rs2154310007 | 3:33,686,383 | T/A | — | uncertain significance |
| rs1559568830 | 3:33,704,956 | C/T | — | uncertain significance |
| rs185871021 | 3:33,704,962 | G/A | — | likely benign |
| rs78304223 | 3:33,725,866 | T/C | — | benign |
| rs781397391 | 3:33,725,922 | T/C | — | uncertain significance |
| rs752018746 | 3:33,728,570 | A/C | — | uncertain significance |
| rs143967899 | 3:33,728,588 | T/C | — | benign |
| rs61738888 | 3:33,728,610 | G/A | — | benign |
| rs754783224 | 3:33,729,827 | G/A | — | uncertain significance |
| rs1366131912 | 3:33,731,407 | C/A | — | uncertain significance |
| rs181608554 | 3:33,731,434 | G/A | — | likely benign |
| rs371839059 | 3:33,738,358 | T/C | — | uncertain significance |
| rs1317179178 | 3:33,738,404 | T/C | — | uncertain significance |
| rs563984470 | 3:33,756,064 | G/A | — | — |
| rs189397130 | 3:33,759,324 | G/A | — | benign |
| rs376954877 | 3:33,759,356 | G/T | — | uncertain significance |
| rs943021481 | 3:33,759,403 | T/C | — | uncertain significance |
| rs550533307 | 3:33,759,413 | G/A | — | uncertain significance |
| rs371081700 | 3:33,759,458 | C/T | — | uncertain significance |
| rs1206010372 | 3:33,759,481 | C/A | — | uncertain significance |
| rs936774619 | 3:33,759,489 | C/T | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.