CLC
Charcot-Leyden crystal galectin
Summary
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]
Known Variants16 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4802054 | 19:40,221,564 | A/C | downstream gene variant | — |
| rs117361485 | 19:40,222,060 | A/C | — | benign |
| rs750982874 | 19:40,222,145 | C/A | — | uncertain significance |
| rs12977184 | 19:40,222,801 | A/G | — | — |
| rs7249415 | 19:40,223,579 | C/A | intron variant | — |
| rs7253094 | 19:40,223,884 | G/T | — | — |
| rs2514764335 | 19:40,224,954 | A/G | — | uncertain significance |
| rs146776010 | 19:40,225,031 | G/C | — | benign |
| rs765426811 | 19:40,225,047 | C/T | — | uncertain significance |
| rs776178968 | 19:40,225,105 | G/A | — | uncertain significance |
| rs17608 | 19:40,225,646 | G/A | missense variant | — |
| rs372902 | 19:40,226,130 | C/T | intron variant | — |
| rs143121234 | 19:40,226,530 | C/G | intron variant | — |
| rs385240 | 19:40,227,363 | C/A | — | — |
| rs364911 | 19:40,228,350 | T/C | intron variant | — |
| rs12611334 | 19:40,229,409 | C/G | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.