CLEC1B
C-type lectin domain family 1 member B
Summary
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]
Known Variants26 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs202115320 | 12:10,145,767 | A/T | — | uncertain significance |
| rs1591846477 | 12:10,145,857 | T/A | — | uncertain significance |
| rs1430776670 | 12:10,145,866 | C/G | — | uncertain significance |
| rs151198877 | 12:10,147,310 | C/G | intron variant | — |
| rs201431937 | 12:10,147,775 | C/G | — | uncertain significance |
| rs374690524 | 12:10,149,481 | A/C | — | uncertain significance |
| rs763938177 | 12:10,149,504 | T/C | — | uncertain significance |
| rs767522010 | 12:10,149,524 | T/C | — | uncertain significance |
| rs1312004402 | 12:10,149,530 | C/G | — | uncertain significance |
| rs545436774 | 12:10,149,542 | T/A | — | uncertain significance |
| rs367744891 | 12:10,149,563 | C/T | — | uncertain significance |
| rs777409260 | 12:10,149,597 | C/A | — | uncertain significance |
| rs765309726 | 12:10,149,801 | A/T | — | uncertain significance |
| rs200797571 | 12:10,149,806 | C/T | — | uncertain significance |
| rs200687802 | 12:10,149,814 | T/A | — | uncertain significance |
| rs1324215489 | 12:10,149,819 | G/C | — | uncertain significance |
| rs1230571774 | 12:10,149,834 | T/C | — | uncertain significance |
| rs548647712 | 12:10,149,837 | G/C | — | uncertain significance |
| rs776714738 | 12:10,149,848 | T/C | — | uncertain significance |
| rs776122981 | 12:10,149,855 | G/T | — | uncertain significance |
| rs1591852060 | 12:10,149,861 | A/G | — | uncertain significance |
| rs201996581 | 12:10,150,874 | C/T | splice region variant | — |
| rs199738622 | 12:10,150,908 | C/A | — | uncertain significance |
| rs200670719 | 12:10,150,916 | C/A | — | uncertain significance |
| rs2137245159 | 12:10,150,944 | C/A | — | uncertain significance |
| rs376698380 | 12:10,150,967 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.