CLEC4G
C-type lectin domain family 4 member G
Summary
This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]
Known Variants10 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1014021042 | 19:7,794,308 | C/T | — | uncertain significance |
| rs1439206869 | 19:7,794,773 | C/T | — | uncertain significance |
| rs2512279174 | 19:7,794,946 | C/A | — | uncertain significance |
| rs773992274 | 19:7,795,029 | G/A | — | uncertain significance |
| rs1232676170 | 19:7,795,703 | A/G | — | uncertain significance |
| rs2512281034 | 19:7,796,595 | C/T | — | uncertain significance |
| rs1294612150 | 19:7,796,646 | G/A | — | uncertain significance |
| rs2033441704 | 19:7,796,949 | C/T | — | uncertain significance |
| rs4804790 | 19:7,797,154 | G/T | regulatory region variant | — |
| rs11669411 | 19:7,797,612 | A/C | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.