CNKSR2

connector enhancer of kinase suppressor of Ras 2

Summary

This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Known Variants139 total

rsidPosition (GRCh37)AllelesClassClinVar
rs2090566346X:21,444,623G/A—uncertain significance
rs886041712X:21,444,664——pathogenic
rs2518787428X:21,444,669G/A—uncertain significance
rs1569161669X:21,444,678A/G—uncertain significance
rs756206673X:21,444,686C/T—uncertain significance
rs1397199866X:21,444,726G/A—uncertain significance
rs2518787800X:21,444,729T/C—uncertain significance
rs757776373X:21,444,742A/G—conflicting classifications of pathogenicity
rs2518787877X:21,444,746A/G—uncertain significance
rs1569161831X:21,444,779G/A—likely pathogenic
rs1167304415X:21,450,779A/G—uncertain significance
rs2518807154X:21,450,787G/A—uncertain significance
rs2090650922X:21,450,799C/T—pathogenic
rs1275639428X:21,450,815G/A—uncertain significance
rs554125982X:21,450,864A/G—likely benign
rs1240294498X:21,458,815A/G—likely benign
rs2090771770X:21,458,816C/G—uncertain significance
rs2518828993X:21,458,832C/G—uncertain significance
rs2518829058X:21,458,843G/T—uncertain significance
rs376118490X:21,458,857T/C—likely benign
rs34161348X:21,488,889T/C—benign
rs2518911519X:21,488,890A/T—uncertain significance
rs2518911781X:21,488,927T/G—uncertain significance
rs73203336X:21,489,459C/Tintron variant—
rs62590551X:21,494,390A/Gintron variant—
rs1056734035X:21,508,603C/A—uncertain significance
rs759415675X:21,508,607A/G—uncertain significance
rs77732468X:21,508,666A/G—benign
rs375737212X:21,508,687C/T—likely benign
rs2518970563X:21,508,705T/C—likely benign
rs2518990270X:21,515,937C/G—uncertain significance
rs372333253X:21,515,968A/G—uncertain significance
rs2519001813X:21,519,674G/A—uncertain significance
rs2147096420X:21,534,639C/T—pathogenic
rs2147096468X:21,534,660A/G—uncertain significance
rs201553334X:21,534,688G/A—uncertain significance
rs2519082024X:21,544,980A/G—uncertain significance
rs2091840428X:21,544,984G/A—uncertain significance
rs2519082137X:21,544,986C/T—uncertain significance
rs2519082359X:21,545,009A/G—uncertain significance
rs759498814X:21,545,015G/A—likely benign
rs2519082614X:21,545,028C/T—uncertain significance
rs2091841106X:21,545,030A/G—uncertain significance
rs1173210591X:21,545,111A/G—uncertain significance
rs2519083192X:21,545,117A/G—likely pathogenic
rs2091889230X:21,549,975G/A—uncertain significance
rs151168016X:21,549,997G/C—uncertain significance
rs2519100957X:21,550,005C/T—uncertain significance
rs2519101094X:21,550,020G/A—uncertain significance
rs2519101342X:21,550,080C/T—pathogenic
rs2091890198X:21,550,101G/A—uncertain significance
rs2147123782X:21,550,117T/A—pathogenic
rs1419864564X:21,550,150G/A—uncertain significance
rs1064794022X:21,550,164C/Tstop gainedpathogenic
rs775075264X:21,550,171G/A—uncertain significance
rs1177611894X:21,550,174C/T—uncertain significance
rs1555941759X:21,550,186G/C—likely pathogenic
rs6633421X:21,569,920A/C——
rs2092188951X:21,579,618G/C—uncertain significance
rs2519208511X:21,579,644A/T—uncertain significance
rs2092208925X:21,581,409A/G—uncertain significance
rs760890681X:21,581,420A/G—conflicting classifications of pathogenicity
rs144866575X:21,581,459G/A—likely benign
rs2519215374X:21,581,467A/G—uncertain significance
rs1160732613X:21,581,499C/T—uncertain significance
rs2147191275X:21,581,526C/T—likely pathogenic
rs2519215869X:21,581,554A/C—uncertain significance
rs2092414327X:21,608,696C/T—likely pathogenic
rs2519299753X:21,608,739G/A—likely pathogenic
rs193261661X:21,608,907A/T—likely benign
rs371945192X:21,609,159C/T—likely benign
rs2092417438X:21,609,161A/G—uncertain significance
rs2092417476X:21,609,167G/A—uncertain significance
rs2092417660X:21,609,193G/A—uncertain significance
rs1569261319X:21,609,216G/A—pathogenic
rs2147250007X:21,609,217A/T—pathogenic
rs1045082064X:21,609,231G/A—likely benign
rs1003662009X:21,609,287C/A—uncertain significance
rs750208984X:21,613,156G/A—uncertain significance
rs2519317770X:21,613,171T/C—uncertain significance
rs2147258522X:21,613,440A/G—pathogenic
rs2092480152X:21,619,399G/A—pathogenic
rs2519335839X:21,619,430A/G—likely benign
rs2147268813X:21,619,464C/T—pathogenic
rs757338945X:21,619,465A/G—likely benign
rs757576213X:21,624,947A/C—uncertain significance
rs904072058X:21,624,986C/Tstop gainedpathogenic
rs747391941X:21,624,997G/T—uncertain significance
rs1064793729X:21,624,998G/A—pathogenic
rs780184046X:21,627,195T/A—uncertain significance
rs751955877X:21,627,197C/T—likely benign
rs2519358174X:21,627,228C/T—pathogenic
rs113091231X:21,627,242G/A—conflicting classifications of pathogenicity
rs1064794868X:21,627,267C/T—uncertain significance
rs2519358430X:21,627,271A/C—uncertain significance
rs1160554444X:21,627,291A/T—likely benign
rs1569272271X:21,627,343C/T—likely pathogenic
rs2147283343X:21,627,379C/G—pathogenic
rs886041798X:21,627,383——pathogenic
rs2147283373X:21,627,388A/G—uncertain significance

Showing 100 of 139 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.