CORIN
corin, serine peptidase
Summary
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Known Variants117 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs3749585 | 4:47,597,590 | A/G | downstream gene variant | — |
| rs76700540 | 4:47,597,749 | G/C | — | uncertain significance |
| rs746356819 | 4:47,597,799 | A/C | — | uncertain significance |
| rs749607630 | 4:47,597,812 | C/T | — | uncertain significance |
| rs149439710 | 4:47,597,878 | G/A | — | uncertain significance |
| rs1341180862 | 4:47,597,901 | A/T | — | uncertain significance |
| rs772140616 | 4:47,597,911 | C/A | — | uncertain significance |
| rs1029453560 | 4:47,597,920 | C/T | — | uncertain significance |
| rs1012680486 | 4:47,602,250 | C/T | — | uncertain significance |
| rs774288007 | 4:47,602,259 | T/C | — | uncertain significance |
| rs982157686 | 4:47,602,331 | A/G | — | uncertain significance |
| rs144827232 | 4:47,602,334 | C/T | — | uncertain significance |
| rs751708235 | 4:47,602,335 | G/A | — | uncertain significance |
| rs73815721 | 4:47,605,421 | G/T | — | benign |
| rs774046821 | 4:47,605,465 | C/T | — | uncertain significance |
| rs150816024 | 4:47,605,569 | C/T | — | uncertain significance |
| rs571162211 | 4:47,605,609 | G/A | — | uncertain significance |
| rs1577728243 | 4:47,605,628 | T/A | — | likely benign |
| rs763146479 | 4:47,605,645 | T/A | — | uncertain significance |
| rs750452719 | 4:47,605,648 | T/A | — | uncertain significance |
| rs1170637309 | 4:47,605,668 | A/C | — | uncertain significance |
| rs376924333 | 4:47,605,669 | C/T | — | uncertain significance |
| rs10031014 | 4:47,624,268 | G/C | — | — |
| rs12332061 | 4:47,625,222 | G/T | — | — |
| rs757886805 | 4:47,625,592 | C/T | — | uncertain significance |
| rs1436374067 | 4:47,625,639 | C/G | — | uncertain significance |
| rs149965013 | 4:47,625,648 | A/G | — | uncertain significance |
| rs536003106 | 4:47,625,708 | G/A | — | uncertain significance |
| rs75141391 | 4:47,625,753 | C/T | — | benign |
| rs1033241784 | 4:47,625,913 | C/T | — | likely benign |
| rs371632457 | 4:47,625,936 | G/T | — | uncertain significance |
| rs1722567706 | 4:47,628,437 | T/C | — | uncertain significance |
| rs61759683 | 4:47,628,448 | G/A | — | benign |
| rs534694649 | 4:47,628,449 | G/A | — | uncertain significance |
| rs147988505 | 4:47,628,455 | T/C | — | uncertain significance |
| rs2475207620 | 4:47,628,459 | G/A | — | uncertain significance |
| rs140700496 | 4:47,628,482 | G/C | — | uncertain significance |
| rs200322797 | 4:47,628,504 | C/T | — | uncertain significance |
| rs56004491 | 4:47,628,545 | C/T | — | likely benign |
| rs28729388 | 4:47,638,863 | C/T | intron variant | — |
| rs757124949 | 4:47,643,949 | T/G | — | uncertain significance |
| rs764059963 | 4:47,644,016 | C/A | — | likely benign |
| rs750061020 | 4:47,644,039 | G/A | — | uncertain significance |
| rs1336236562 | 4:47,644,040 | A/T | — | uncertain significance |
| rs545955410 | 4:47,644,981 | G/A | — | likely benign |
| rs55932196 | 4:47,645,061 | A/G | — | benign |
| rs144722161 | 4:47,645,184 | T/A | — | likely benign |
| rs59324344 | 4:47,646,088 | G/T | — | — |
| rs1014486154 | 4:47,647,179 | A/T | — | uncertain significance |
| rs139956578 | 4:47,647,202 | T/C | — | uncertain significance |
| rs1174848143 | 4:47,655,603 | C/T | — | uncertain significance |
| rs200652865 | 4:47,655,618 | A/G | — | uncertain significance |
| rs139281421 | 4:47,655,636 | C/T | — | uncertain significance |
| rs2475296649 | 4:47,655,644 | C/A | — | uncertain significance |
| rs61760480 | 4:47,655,650 | C/T | — | uncertain significance |
| rs147248661 | 4:47,663,741 | A/C | — | uncertain significance |
| rs111253292 | 4:47,663,760 | T/G | — | benign |
| rs75770792 | 4:47,663,799 | G/A | — | benign |
| rs374976508 | 4:47,663,839 | A/T | — | uncertain significance |
| rs201223301 | 4:47,663,848 | G/A | — | uncertain significance |
| rs527634306 | 4:47,667,065 | G/A | — | likely benign |
| rs387906895 | 4:47,667,224 | T/C | missense variant | pathogenic |
| rs867337911 | 4:47,667,226 | G/T | — | uncertain significance |
| rs193921036 | 4:47,667,238 | G/C | — | uncertain significance |
| rs749117753 | 4:47,667,248 | T/C | — | uncertain significance |
| rs373873941 | 4:47,676,433 | G/A | — | likely benign |
| rs764822862 | 4:47,676,452 | C/T | — | uncertain significance |
| rs564704370 | 4:47,679,997 | C/T | — | uncertain significance |
| rs145008247 | 4:47,680,001 | A/G | — | benign |
| rs61760501 | 4:47,680,016 | C/T | — | likely benign |
| rs528926972 | 4:47,680,050 | A/C | — | uncertain significance |
| rs1341108737 | 4:47,680,057 | C/A | — | uncertain significance |
| rs200150723 | 4:47,680,081 | A/G | — | benign |
| rs2271037 | 4:47,680,085 | T/G | intron variant | — |
| rs150957535 | 4:47,682,191 | C/T | — | uncertain significance |
| rs771465430 | 4:47,682,192 | G/T | — | uncertain significance |
| rs1227232210 | 4:47,682,199 | C/T | — | uncertain significance |
| rs139499566 | 4:47,682,209 | C/T | — | uncertain significance |
| rs149671375 | 4:47,682,221 | C/A | — | uncertain significance |
| rs147781342 | 4:47,682,229 | C/T | — | uncertain significance |
| rs368765606 | 4:47,682,239 | C/A | — | uncertain significance |
| rs1560502777 | 4:47,682,257 | T/C | — | uncertain significance |
| rs185899169 | 4:47,685,768 | A/C | — | benign |
| rs387906894 | 4:47,685,820 | T/C | missense variant | pathogenic |
| rs368796097 | 4:47,695,050 | G/A | — | uncertain significance |
| rs201365573 | 4:47,695,065 | T/C | — | uncertain significance |
| rs763380815 | 4:47,695,085 | C/T | — | uncertain significance |
| rs1286949365 | 4:47,746,436 | T/C | — | uncertain significance |
| rs543437458 | 4:47,746,469 | C/T | — | uncertain significance |
| rs567348021 | 4:47,746,480 | T/C | — | likely benign |
| rs773644434 | 4:47,746,489 | A/C | — | uncertain significance |
| rs141909615 | 4:47,746,514 | G/A | — | uncertain significance |
| rs111915728 | 4:47,765,389 | G/A | — | benign |
| rs554037472 | 4:47,765,403 | C/T | — | uncertain significance |
| rs141945729 | 4:47,765,462 | T/A | — | uncertain significance |
| rs199725087 | 4:47,765,475 | G/A | — | uncertain significance |
| rs1436096655 | 4:47,765,538 | G/A | — | uncertain significance |
| rs751045278 | 4:47,765,541 | G/A | — | uncertain significance |
| rs543562166 | 4:47,765,549 | G/A | — | uncertain significance |
| rs144005444 | 4:47,765,585 | G/T | — | uncertain significance |
Showing 100 of 117 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.