CORO2A
coronin 2A
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Known Variants39 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs369926939 | 9:100,887,078 | C/T | — | uncertain significance |
| rs776771810 | 9:100,887,108 | T/C | — | uncertain significance |
| rs771489458 | 9:100,888,866 | C/T | — | likely benign |
| rs112540774 | 9:100,888,891 | T/G | — | uncertain significance |
| rs3174288 | 9:100,889,004 | G/A | — | uncertain significance |
| rs149125179 | 9:100,889,097 | G/C | — | uncertain significance |
| rs748104776 | 9:100,890,518 | A/G | — | uncertain significance |
| rs747978763 | 9:100,890,953 | C/T | — | uncertain significance |
| rs144120813 | 9:100,892,102 | C/T | — | uncertain significance |
| rs545069359 | 9:100,892,103 | G/A | — | uncertain significance |
| rs201065478 | 9:100,892,129 | G/C | — | uncertain significance |
| rs1372124717 | 9:100,892,134 | G/C | — | uncertain significance |
| rs1339033240 | 9:100,893,265 | T/G | — | uncertain significance |
| rs369134629 | 9:100,893,269 | C/T | — | uncertain significance |
| rs377675370 | 9:100,894,490 | G/A | — | uncertain significance |
| rs779049528 | 9:100,894,546 | A/G | — | uncertain significance |
| rs957426024 | 9:100,895,339 | C/T | — | uncertain significance |
| rs2490791777 | 9:100,895,352 | C/T | — | likely benign |
| rs146003769 | 9:100,895,355 | G/A | — | uncertain significance |
| rs148208416 | 9:100,895,369 | T/C | — | uncertain significance |
| rs2490791898 | 9:100,895,370 | T/C | — | uncertain significance |
| rs2490791940 | 9:100,895,391 | T/C | — | uncertain significance |
| rs754870538 | 9:100,897,095 | T/C | — | uncertain significance |
| rs145697411 | 9:100,897,123 | C/T | — | uncertain significance |
| rs148959568 | 9:100,897,126 | C/T | — | uncertain significance |
| rs575343616 | 9:100,897,158 | C/T | — | uncertain significance |
| rs2231660 | 9:100,897,162 | C/T | — | uncertain significance |
| rs142497032 | 9:100,897,191 | G/A | — | uncertain significance |
| rs2231658 | 9:100,899,934 | C/T | — | uncertain significance |
| rs73655199 | 9:100,907,483 | G/A | intron variant | — |
| rs375269323 | 9:100,919,759 | C/T | — | uncertain significance |
| rs137868323 | 9:100,919,808 | G/A | — | likely benign |
| rs1393098252 | 9:100,919,823 | G/C | — | uncertain significance |
| rs770982762 | 9:100,919,846 | G/A | — | uncertain significance |
| rs201807340 | 9:100,919,858 | C/T | — | uncertain significance |
| rs371225634 | 9:100,919,879 | T/C | — | uncertain significance |
| rs777631086 | 9:100,919,906 | G/A | — | uncertain significance |
| rs2490844830 | 9:100,919,935 | C/A | — | uncertain significance |
| rs1985859 | 9:100,936,113 | T/C | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.