CRHBP
corticotropin releasing hormone binding protein
Summary
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
Known Variants23 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs3792738 | 5:76,247,784 | C/A | upstream gene variant | — |
| rs28365143 | 5:76,248,086 | G/A | upstream gene variant | — |
| rs1580088679 | 5:76,248,999 | A/G | — | uncertain significance |
| rs2531385011 | 5:76,249,493 | G/C | — | uncertain significance |
| rs78115247 | 5:76,249,503 | G/A | — | benign |
| rs772324107 | 5:76,249,854 | G/A | — | uncertain significance |
| rs377064988 | 5:76,249,901 | G/A | — | uncertain significance |
| rs147365557 | 5:76,249,905 | G/T | — | uncertain significance |
| rs34761141 | 5:76,249,945 | C/G | — | benign |
| rs2531386836 | 5:76,249,970 | G/C | — | uncertain significance |
| rs7721799 | 5:76,250,378 | G/A | regulatory region variant | — |
| rs32897 | 5:76,250,972 | T/C | intron variant | — |
| rs1257109599 | 5:76,251,512 | T/C | — | uncertain significance |
| rs748736594 | 5:76,254,694 | G/A | — | uncertain significance |
| rs189832182 | 5:76,255,599 | G/C | regulatory region variant | — |
| rs7718461 | 5:76,258,048 | A/T | — | — |
| rs2531404908 | 5:76,259,180 | G/A | — | uncertain significance |
| rs541282053 | 5:76,259,194 | A/G | — | uncertain significance |
| rs10062367 | 5:76,264,354 | G/A | intron variant | — |
| rs757944609 | 5:76,264,621 | G/T | — | uncertain significance |
| rs1407656696 | 5:76,264,654 | G/A | — | uncertain significance |
| rs1875999 | 5:76,264,982 | T/A | — | — |
| rs1053989 | 5:76,265,035 | C/A | 3 prime UTR variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.