CRLF3
cytokine receptor like factor 3
Summary
This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]
Known Variants22 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2509938456 | 17:29,111,264 | C/G | — | uncertain significance |
| rs774812659 | 17:29,112,966 | C/T | — | uncertain significance |
| rs202168619 | 17:29,112,979 | C/T | — | uncertain significance |
| rs375561031 | 17:29,112,997 | C/G | — | uncertain significance |
| rs148611709 | 17:29,117,833 | A/G | coding sequence variant | — |
| rs1971824411 | 17:29,119,478 | A/C | — | uncertain significance |
| rs751773627 | 17:29,119,495 | C/A | — | uncertain significance |
| rs200175473 | 17:29,119,515 | G/A | — | uncertain significance |
| rs7221134 | 17:29,119,941 | G/A | — | — |
| rs368649092 | 17:29,120,485 | G/C | — | uncertain significance |
| rs139102054 | 17:29,120,588 | C/T | — | uncertain significance |
| rs757714963 | 17:29,120,612 | C/T | — | uncertain significance |
| rs374857610 | 17:29,120,618 | C/G | — | uncertain significance |
| rs371114832 | 17:29,120,669 | G/C | — | uncertain significance |
| rs9915567 | 17:29,122,478 | T/A | — | — |
| rs71372238 | 17:29,128,573 | C/G | intron variant | — |
| rs116524302 | 17:29,130,192 | A/T | intron variant | — |
| rs1972047392 | 17:29,131,027 | G/A | — | uncertain significance |
| rs62070638 | 17:29,137,678 | A/G | intron variant | — |
| rs769371660 | 17:29,151,558 | G/A | — | uncertain significance |
| rs776835751 | 17:29,151,636 | G/C | — | uncertain significance |
| rs148454306 | 17:29,151,646 | C/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.