CSF3

colony stimulating factor 3

Summary

This gene encodes a member of the IL-6 superfamily of cytokines. The encoded cytokine controls the production, differentiation, and function of granulocytes. Granulocytes are a type of white blood cell that are part of the innate immune response. A modified form of this protein is commonly administered to manage chemotherapy-induced neutropenia. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2020]

Known Variants17 total

rsidPosition (GRCh37)AllelesClassClinVar
rs222732217:38,171,668C/Gdownstream gene variant
rs254404091017:38,171,741C/Tuncertain significance
rs75546248617:38,171,967A/Guncertain significance
rs14149000817:38,171,973C/Tuncertain significance
rs14635293817:38,172,071C/Tbenign
rs36853098717:38,172,078G/Auncertain significance
rs74901264217:38,172,567A/Guncertain significance
rs254404391217:38,172,762A/Guncertain significance
rs254404393817:38,172,772T/Guncertain significance
rs14228614217:38,172,820T/Cmissense variant
rs254404407317:38,172,831T/Guncertain significance
rs928266117:38,173,040C/Gbenign
rs222732917:38,173,057C/Abenign
rs928266017:38,173,101G/Tbenign
rs77491221217:38,173,107C/Tbenign
rs222733017:38,173,108G/Abenign
rs104265817:38,173,902C/Tdownstream gene variant

Gene information from NCBI Gene. Variant classifications from ClinVar.