CSF3
colony stimulating factor 3
Summary
This gene encodes a member of the IL-6 superfamily of cytokines. The encoded cytokine controls the production, differentiation, and function of granulocytes. Granulocytes are a type of white blood cell that are part of the innate immune response. A modified form of this protein is commonly administered to manage chemotherapy-induced neutropenia. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2020]
Known Variants17 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2227322 | 17:38,171,668 | C/G | downstream gene variant | — |
| rs2544040910 | 17:38,171,741 | C/T | — | uncertain significance |
| rs755462486 | 17:38,171,967 | A/G | — | uncertain significance |
| rs141490008 | 17:38,171,973 | C/T | — | uncertain significance |
| rs146352938 | 17:38,172,071 | C/T | — | benign |
| rs368530987 | 17:38,172,078 | G/A | — | uncertain significance |
| rs749012642 | 17:38,172,567 | A/G | — | uncertain significance |
| rs2544043912 | 17:38,172,762 | A/G | — | uncertain significance |
| rs2544043938 | 17:38,172,772 | T/G | — | uncertain significance |
| rs142286142 | 17:38,172,820 | T/C | missense variant | — |
| rs2544044073 | 17:38,172,831 | T/G | — | uncertain significance |
| rs9282661 | 17:38,173,040 | C/G | — | benign |
| rs2227329 | 17:38,173,057 | C/A | — | benign |
| rs9282660 | 17:38,173,101 | G/T | — | benign |
| rs774912212 | 17:38,173,107 | C/T | — | benign |
| rs2227330 | 17:38,173,108 | G/A | — | benign |
| rs1042658 | 17:38,173,902 | C/T | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.