CST1
cystatin SN
Summary
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid. [provided by RefSeq, Jul 2008]
Known Variants27 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs6049067 | 20:23,727,828 | C/G | downstream gene variant | — |
| rs149946437 | 20:23,728,486 | C/A | — | uncertain significance |
| rs3188320 | 20:23,728,487 | C/A | — | likely benign |
| rs3188319 | 20:23,728,494 | T/C | — | likely benign |
| rs367602743 | 20:23,728,509 | C/T | — | uncertain significance |
| rs113478826 | 20:23,729,282 | T/C | intron variant | — |
| rs762843755 | 20:23,729,678 | A/G | — | uncertain significance |
| rs750079881 | 20:23,729,709 | T/C | — | uncertain significance |
| rs201505177 | 20:23,729,736 | C/T | — | uncertain significance |
| rs4260306 | 20:23,730,336 | C/T | intron variant | — |
| rs768059525 | 20:23,731,299 | G/A | — | uncertain significance |
| rs759636003 | 20:23,731,304 | G/A | — | uncertain significance |
| rs373670958 | 20:23,731,305 | G/C | — | uncertain significance |
| rs151291851 | 20:23,731,322 | T/A | — | uncertain significance |
| rs368203290 | 20:23,731,344 | C/T | — | uncertain significance |
| rs2514816265 | 20:23,731,346 | C/T | — | uncertain significance |
| rs77188058 | 20:23,731,385 | T/C | missense variant | — |
| rs117238940 | 20:23,731,389 | G/T | — | uncertain significance |
| rs2514816337 | 20:23,731,404 | T/G | — | uncertain significance |
| rs146601403 | 20:23,731,406 | C/A | — | uncertain significance |
| rs756160302 | 20:23,731,418 | A/T | — | uncertain significance |
| rs760570692 | 20:23,731,452 | C/T | — | uncertain significance |
| rs141813234 | 20:23,731,465 | G/A | — | likely benign |
| rs144543419 | 20:23,731,477 | C/T | — | likely benign |
| rs2122677428 | 20:23,731,487 | C/T | — | uncertain significance |
| rs772372352 | 20:23,731,493 | T/G | — | uncertain significance |
| rs776620783 | 20:23,731,496 | T/C | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.