CYBRD1

cytochrome b reductase 1

Summary

This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008]

Known Variants26 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs884409	2:172,378,657	T/G	regulatory region variant	—
rs868106	2:172,378,818	A/G	regulatory region variant	—
rs749449959	2:172,379,071	T/C	—	uncertain significance
rs146713767	2:172,379,099	C/T	—	likely benign
rs201989257	2:172,379,158	C/G	—	uncertain significance
rs1384197020	2:172,379,228	T/G	—	uncertain significance
rs754748261	2:172,379,230	G/A	—	uncertain significance
rs767447864	2:172,379,233	T/C	—	uncertain significance
rs151054210	2:172,381,487	G/A	intron variant	—
rs62181672	2:172,386,293	T/C	intron variant	—
rs760252994	2:172,398,179	C/T	—	uncertain significance
rs1404374068	2:172,398,187	C/T	—	uncertain significance
rs2529921337	2:172,398,193	A/G	—	uncertain significance
rs139126991	2:172,398,244	A/G	—	uncertain significance
rs1201207482	2:172,398,269	T/C	—	uncertain significance
rs55877758	2:172,409,030	T/A	intron variant	—
rs202158377	2:172,409,897	G/A	—	likely benign
rs145340565	2:172,409,980	T/C	—	uncertain significance
rs200712533	2:172,409,981	G/A	—	uncertain significance
rs144760480	2:172,411,060	C/T	—	uncertain significance
rs2529946545	2:172,411,114	C/A	—	uncertain significance
rs150461979	2:172,411,142	G/A	—	likely benign
rs10455	2:172,411,273	G/A	missense variant	benign
rs998194468	2:172,411,324	G/A	—	uncertain significance
rs1606927	2:172,414,895	C/T	—	—
rs191516412	2:172,415,019	T/A	downstream gene variant	—

Gene information from NCBI Gene. Variant classifications from ClinVar.