CYP4A22
cytochrome P450 family 4 subfamily A member 22
Pharmacogene
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Known Variants41 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs76011927 | 1:47,137,516 | C/T | missense variant | — |
| rs2056900 | 1:47,142,113 | G/A | missense variant | — |
| rs4926581 | 1:47,143,311 | G/T | missense variant | — |
| rs10789501 | 1:47,143,817 | T/C | missense variant | association |
| rs6661132 | 1:47,144,393 | A/C | missense variant | — |
| rs201802480 | 1:47,144,551 | TG/T | frameshift variant | — |
| rs759296620 | 1:47,603,210 | T/C | — | uncertain significance |
| rs534701920 | 1:47,603,297 | C/G | — | uncertain significance |
| rs1215996583 | 1:47,606,452 | T/C | — | uncertain significance |
| rs370585374 | 1:47,606,460 | C/G | — | likely benign |
| rs759156135 | 1:47,606,555 | A/G | — | uncertain significance |
| rs189269010 | 1:47,607,883 | G/A | — | uncertain significance |
| rs201496093 | 1:47,607,897 | G/A | — | uncertain significance |
| rs774514132 | 1:47,609,013 | G/A | — | uncertain significance |
| rs1224945328 | 1:47,609,030 | T/G | — | uncertain significance |
| rs183880611 | 1:47,609,504 | T/G | — | uncertain significance |
| rs199906672 | 1:47,609,523 | T/A | — | uncertain significance |
| rs769147059 | 1:47,609,529 | G/A | — | uncertain significance |
| rs536116490 | 1:47,609,559 | G/A | — | uncertain significance |
| rs376758503 | 1:47,609,561 | G/A | — | uncertain significance |
| rs779166657 | 1:47,609,586 | C/T | — | uncertain significance |
| rs760627269 | 1:47,610,069 | G/T | — | uncertain significance |
| rs2522525565 | 1:47,610,079 | G/A | — | uncertain significance |
| rs556570340 | 1:47,610,089 | A/T | — | uncertain significance |
| rs369645508 | 1:47,610,314 | C/G | — | uncertain significance |
| rs762145254 | 1:47,610,325 | T/C | — | uncertain significance |
| rs745735706 | 1:47,610,352 | A/T | — | uncertain significance |
| rs200956466 | 1:47,610,406 | T/C | — | uncertain significance |
| rs967716185 | 1:47,610,554 | G/C | — | uncertain significance |
| rs1481167725 | 1:47,610,582 | G/A | — | uncertain significance |
| rs1313994102 | 1:47,610,603 | A/G | — | uncertain significance |
| rs148459778 | 1:47,610,625 | G/C | — | uncertain significance |
| rs1289669941 | 1:47,611,578 | C/A | — | uncertain significance |
| rs1450216767 | 1:47,611,585 | G/T | — | uncertain significance |
| rs1366357088 | 1:47,611,750 | T/G | — | uncertain significance |
| rs765462401 | 1:47,611,798 | C/T | — | uncertain significance |
| rs554623281 | 1:47,614,284 | G/A | — | uncertain significance |
| rs540636031 | 1:47,614,324 | C/G | — | uncertain significance |
| rs1645100981 | 1:47,614,380 | A/G | — | uncertain significance |
| rs773718162 | 1:47,614,392 | G/C | — | uncertain significance |
| rs1557651275 | 1:47,614,458 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.