DACT2
dishevelled binding antagonist of beta catenin 2
Summary
Predicted to enable several functions, including beta-catenin binding activity; delta-catenin binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including epithelial cell morphogenesis; inner medullary collecting duct development; and negative regulation of nodal signaling pathway. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants72 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs12204529 | 6:168,698,932 | C/G | coding sequence variant | — |
| rs3800537 | 6:168,700,040 | A/G | coding sequence variant | — |
| rs761233827 | 6:168,708,263 | G/A | — | uncertain significance |
| rs191740169 | 6:168,708,270 | C/T | — | uncertain significance |
| rs2533575313 | 6:168,708,300 | A/G | — | uncertain significance |
| rs370941715 | 6:168,708,315 | C/T | — | uncertain significance |
| rs78695494 | 6:168,708,316 | G/A | — | benign |
| rs376125439 | 6:168,708,327 | C/T | — | uncertain significance |
| rs548434672 | 6:168,708,354 | C/T | — | uncertain significance |
| rs549907362 | 6:168,708,380 | G/T | — | uncertain significance |
| rs1202698562 | 6:168,708,390 | C/T | — | uncertain significance |
| rs763062891 | 6:168,708,420 | G/A | — | uncertain significance |
| rs779905976 | 6:168,708,467 | G/A | — | uncertain significance |
| rs1779254739 | 6:168,708,468 | T/C | — | likely benign |
| rs891421097 | 6:168,708,534 | C/T | — | likely benign |
| rs1562495020 | 6:168,708,540 | T/C | — | uncertain significance |
| rs1381384600 | 6:168,708,618 | G/A | — | uncertain significance |
| rs183650899 | 6:168,708,652 | C/T | — | likely benign |
| rs763264152 | 6:168,708,653 | G/T | — | uncertain significance |
| rs2533577329 | 6:168,708,671 | G/C | — | uncertain significance |
| rs988553589 | 6:168,708,701 | G/A | — | uncertain significance |
| rs368337356 | 6:168,708,704 | G/T | — | uncertain significance |
| rs995544811 | 6:168,708,795 | G/A | — | uncertain significance |
| rs1372571204 | 6:168,708,896 | G/A | — | uncertain significance |
| rs2533578614 | 6:168,708,933 | T/A | — | uncertain significance |
| rs1317071934 | 6:168,708,943 | T/A | — | uncertain significance |
| rs1291017988 | 6:168,708,954 | T/C | — | uncertain significance |
| rs1010865778 | 6:168,708,966 | G/A | — | uncertain significance |
| rs371278832 | 6:168,708,996 | G/A | — | uncertain significance |
| rs201301805 | 6:168,709,018 | C/T | — | likely benign |
| rs1278280445 | 6:168,709,091 | G/A | — | uncertain significance |
| rs377662346 | 6:168,709,093 | C/G | — | uncertain significance |
| rs778946827 | 6:168,709,124 | A/G | — | likely benign |
| rs921618080 | 6:168,709,166 | C/T | — | uncertain significance |
| rs764133000 | 6:168,709,218 | C/T | — | uncertain significance |
| rs767015702 | 6:168,709,242 | C/T | — | likely benign |
| rs780439375 | 6:168,709,266 | C/G | — | uncertain significance |
| rs370353122 | 6:168,709,272 | C/T | — | uncertain significance |
| rs569343262 | 6:168,709,290 | C/T | — | uncertain significance |
| rs200186315 | 6:168,709,304 | C/T | — | likely benign |
| rs772353783 | 6:168,709,314 | C/T | — | likely benign |
| rs367909442 | 6:168,709,331 | C/G | — | uncertain significance |
| rs1188825052 | 6:168,709,336 | C/A | — | uncertain significance |
| rs769524155 | 6:168,709,355 | G/A | — | uncertain significance |
| rs935216597 | 6:168,709,443 | C/T | — | uncertain significance |
| rs1372609677 | 6:168,709,457 | G/A | — | uncertain significance |
| rs753191558 | 6:168,709,467 | C/T | — | uncertain significance |
| rs570102629 | 6:168,709,475 | G/A | — | likely benign |
| rs1198336544 | 6:168,709,562 | G/A | — | uncertain significance |
| rs1476542521 | 6:168,709,577 | G/A | — | uncertain significance |
| rs2533581622 | 6:168,709,589 | G/A | — | uncertain significance |
| rs759952833 | 6:168,709,656 | G/A | — | uncertain significance |
| rs1779315419 | 6:168,709,659 | A/T | — | uncertain significance |
| rs2533581969 | 6:168,709,664 | G/C | — | uncertain significance |
| rs781619443 | 6:168,709,723 | G/C | — | uncertain significance |
| rs923642835 | 6:168,710,874 | G/A | — | uncertain significance |
| rs757268167 | 6:168,711,017 | C/G | — | uncertain significance |
| rs745324019 | 6:168,711,100 | A/G | — | uncertain significance |
| rs1375540807 | 6:168,711,105 | C/T | — | uncertain significance |
| rs369801873 | 6:168,711,106 | C/T | — | uncertain significance |
| rs1342485076 | 6:168,711,109 | C/T | — | uncertain significance |
| rs1023772319 | 6:168,711,900 | C/G | — | uncertain significance |
| rs1005324468 | 6:168,711,933 | T/C | — | uncertain significance |
| rs535169298 | 6:168,719,980 | C/G | — | — |
| rs1423291438 | 6:168,720,085 | C/A | — | uncertain significance |
| rs1441818728 | 6:168,720,183 | C/G | — | uncertain significance |
| rs1431459784 | 6:168,720,184 | G/C | — | uncertain significance |
| rs948540292 | 6:168,720,236 | G/T | — | likely benign |
| rs767265343 | 6:168,720,280 | C/T | — | likely benign |
| rs2533608046 | 6:168,720,283 | C/T | — | uncertain significance |
| rs1376291368 | 6:168,720,292 | G/A | — | uncertain significance |
| rs1006441345 | 6:168,720,303 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.