DAD1
defender against cell death 1
Summary
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]
Known Variants13 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs5742800 | 14:23,043,693 | T/C | — | benign |
| rs5742799 | 14:23,043,787 | A/G | — | benign |
| rs5742798 | 14:23,043,887 | T/A | — | benign |
| rs1051154 | 14:23,044,004 | C/T | — | benign |
| rs202246203 | 14:23,044,067 | G/C | — | uncertain significance |
| rs5742794 | 14:23,044,261 | A/G | — | benign |
| rs5742793 | 14:23,044,343 | A/G | — | benign |
| rs8005354 | 14:23,050,763 | T/C | intron variant | — |
| rs560404630 | 14:23,051,859 | G/A | — | — |
| rs5742732 | 14:23,057,667 | G/C | — | benign |
| rs146842433 | 14:23,057,999 | T/C | — | uncertain significance |
| rs2502947959 | 14:23,058,041 | A/G | — | uncertain significance |
| rs757044016 | 14:23,058,053 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.