DAO

D-amino acid oxidase

Summary

This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]

Known Variants76 total

rsidPosition (GRCh37)AllelesClassClinVar
rs462395112:109,272,051C/G——
rs797776212:109,275,609C/Tintron variant—
rs207058612:109,277,720G/Aintron variant—
rs7630524912:109,278,540C/T—benign
rs211190212:109,278,747T/Gintron variantbenign
rs77376506412:109,278,786C/A—uncertain significance
rs18108026112:109,278,806A/T—likely benign
rs14654370912:109,278,815C/T—likely benign
rs37391331012:109,278,816G/A—uncertain significance
rs14126383412:109,278,827C/T—likely benign
rs77873560412:109,278,828G/A—conflicting classifications of pathogenicity
rs20035018412:109,278,890G/A—likely benign
rs36809332412:109,278,895G/A—uncertain significance
rs77988182612:109,278,914C/A—likely benign
rs53174917112:109,278,929C/T—likely benign
rs11357645012:109,278,942C/A—uncertain significance
rs120775217912:109,278,955A/T—uncertain significance
rs20104042612:109,278,969C/G—likely benign
rs7586179412:109,281,127C/T—benign
rs117135257812:109,281,219C/T—likely benign
rs13827742012:109,281,243C/T—uncertain significance
rs78165865712:109,281,281G/A—conflicting classifications of pathogenicity
rs14691736112:109,281,299T/G—likely benign
rs798042712:109,281,310G/A—benign
rs3555085912:109,281,331A/G—likely benign
rs20012757612:109,281,339C/T—likely benign
rs14714473312:109,281,340G/A—uncertain significance
rs37304206212:109,281,350C/T—likely benign
rs7803440712:109,281,677A/G—benign
rs391834612:109,281,884G/Aintron variant—
rs53247400512:109,283,249C/G—uncertain significance
rs75697122412:109,283,279G/A—uncertain significance
rs74700232312:109,283,319C/T—likely benign
rs77113938912:109,283,323T/C—likely benign
rs374177512:109,283,603A/Cintron variantbenign
rs653945912:109,283,726A/G—benign
rs74691444612:109,283,983G/A—uncertain significance
rs203947649712:109,283,988G/T—uncertain significance
rs3538842212:109,284,027T/C—likely benign
rs653946212:109,286,146C/A——
rs1111408712:109,286,576G/C—benign
rs156603786412:109,286,788G/A—likely benign
rs145168863312:109,286,795G/T—likely benign
rs37714464612:109,286,807G/A—uncertain significance
rs1704105012:109,286,910G/A—benign
rs1183072512:109,287,728T/C—benign
rs382525112:109,287,984A/Gintron variantbenign
rs19231216812:109,288,033T/C—benign
rs76387674812:109,288,054G/A—uncertain significance
rs37632639512:109,288,070A/G—uncertain significance
rs13916697612:109,288,126C/T—likely benign
rs20085075612:109,288,127G/A—likely benign
rs146740105212:109,290,787C/T—likely benign
rs122620839612:109,290,801A/T—uncertain significance
rs135201586212:109,290,810T/C—uncertain significance
rs5594452912:109,292,430T/C—benign
rs53189291012:109,292,463C/T—uncertain significance
rs14995624112:109,292,482C/T—benign
rs11263473112:109,292,973G/A—benign
rs148877663012:109,293,149C/G—likely benign
rs77209437012:109,293,179T/A—likely benign
rs14355064212:109,293,187G/A—likely benign
rs76840385212:109,293,195C/T—uncertain significance
rs56626461812:109,293,196G/A—uncertain significance
rs37256029512:109,293,208G/A—uncertain significance
rs76043200312:109,293,229G/A—uncertain significance
rs391834712:109,293,320A/Gintron variantbenign
rs7970829812:109,293,417C/T—benign
rs496428112:109,294,051G/A—benign
rs75482892312:109,294,194T/C—likely benign
rs57517007312:109,294,210G/A—uncertain significance
rs74714624812:109,294,220T/G—uncertain significance
rs203961020412:109,294,229G/A—uncertain significance
rs20187944712:109,294,295C/T—uncertain significance
rs14373213212:109,294,301C/T—uncertain significance
rs11598843112:109,294,413T/C—benign

Gene information from NCBI Gene. Variant classifications from ClinVar.