DAW1
dynein assembly factor with WD repeats 1
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in protein polyubiquitination. Predicted to act upstream of with a positive effect on outer dynein arm assembly. Predicted to act upstream of or within with a positive effect on intraciliary transport. Predicted to act upstream of or within several processes, including cerebrospinal fluid circulation; determination of left/right symmetry; and heart development. Predicted to be located in ciliary basal body. Predicted to be part of SCF ubiquitin ligase complex. Implicated in primary ciliary dyskinesia. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants31 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs201688150 | 2:228,736,425 | T/C | — | uncertain significance |
| rs549883706 | 2:228,736,426 | G/T | — | benign |
| rs1179766590 | 2:228,750,094 | G/A | — | uncertain significance |
| rs150347456 | 2:228,754,582 | A/G | — | uncertain significance |
| rs193027901 | 2:228,754,583 | G/C | — | uncertain significance |
| rs975748242 | 2:228,754,586 | C/T | — | uncertain significance |
| rs149371081 | 2:228,754,609 | G/A | — | likely benign |
| rs747333172 | 2:228,754,655 | T/A | — | pathogenic |
| rs746336706 | 2:228,754,681 | G/A | — | uncertain significance |
| rs373453236 | 2:228,754,682 | G/A | — | uncertain significance |
| rs762644243 | 2:228,754,700 | C/T | — | uncertain significance |
| rs201277970 | 2:228,758,545 | C/T | — | uncertain significance |
| rs2106197058 | 2:228,758,550 | G/A | — | pathogenic |
| rs1003401817 | 2:228,758,587 | G/A | — | uncertain significance |
| rs1265774517 | 2:228,758,620 | A/G | — | pathogenic |
| rs372617337 | 2:228,758,624 | A/G | — | uncertain significance |
| rs147460475 | 2:228,758,626 | C/T | — | uncertain significance |
| rs146357367 | 2:228,767,722 | G/T | — | uncertain significance |
| rs139069628 | 2:228,767,755 | C/T | — | uncertain significance |
| rs950649147 | 2:228,767,770 | A/G | — | uncertain significance |
| rs200640275 | 2:228,769,717 | C/T | — | uncertain significance |
| rs139057280 | 2:228,769,729 | G/A | — | uncertain significance |
| rs146121485 | 2:228,771,929 | G/A | — | uncertain significance |
| rs1365625335 | 2:228,771,963 | C/G | — | uncertain significance |
| rs776365595 | 2:228,771,966 | A/C | — | uncertain significance |
| rs1257848643 | 2:228,783,501 | G/A | — | uncertain significance |
| rs1692034631 | 2:228,783,507 | A/G | — | likely benign |
| rs541693633 | 2:228,786,155 | G/C | — | pathogenic |
| rs1435687311 | 2:228,786,180 | G/T | — | pathogenic |
| rs780546827 | 2:228,786,185 | C/T | — | uncertain significance |
| rs181412363 | 2:228,786,283 | G/A | splice region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.